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AP1S2 recombinant protein

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Catalog # MBS204067
Unit / Price
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  0.05 mg  /  $375 +1 FREE 8GB USB
  0.25 mg  /  $925 +1 FREE 8GB USB
SDS-Page
Product Name

AP1S2, Recombinant Protein

Full Product Name

AP1S2, 1-157aa, Human, His tag, E Coli

Product Synonym Names
AP-1 complex subunit sigma-2; DC22; MGC:1902; MRX59; SIGMA1B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT
OMIM
AB015320 mRNA
3D Structure
ModBase 3D Structure for P56377
Host
E Coli
Purity/Purification
> 85% by SDS-PAGE
Form/Format
Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 40% glycerol, 0.1M NaCl, 2mM DTT
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of AP1S2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AP1S2 recombinant protein
AP1S2, also known as AP-1 complex subunit sigma-2, serves as the small subunit of AP-1 complex 1 and is a member of the adaptin protein family. Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. Recombinant human AP1S2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
Product Categories/Family for AP1S2 recombinant protein
Applications Tested/Suitable for AP1S2 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for AP1S2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20.7 kDa (177aa), confirmed by MALDI-TOF
NCBI Official Full Name
AP-1 complex subunit sigma-2 isoform 2
NCBI Official Synonym Full Names
adaptor related protein complex 1 sigma 2 subunit
NCBI Official Symbol
AP1S2  [Similar Products]
NCBI Official Synonym Symbols
PGS; DC22; MRX59; MRXS5; MRXSF; MRXS21; SIGMA1B
  [Similar Products]
NCBI Protein Information
AP-1 complex subunit sigma-2
UniProt Protein Name
AP-1 complex subunit sigma-2
UniProt Synonym Protein Names
Adaptor protein complex AP-1 subunit sigma-1B; Adaptor-related protein complex 1 subunit sigma-1B; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; Sigma 1B subunit of AP-1 clathrin; Sigma-adaptin 1B; Sigma1B-adaptin
UniProt Gene Name
AP1S2  [Similar Products]
NCBI Summary for AP1S2
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for AP1S2
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Product References and Citations for AP1S2 recombinant protein
Tarpey PS. et al. (2006) Am J Hum Genet. 79:1119-24.; Takatsu H. et al. (1998) J Biol Chem. 273 :24693-700

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with AP1S2 recombinant protein
 Reference Product  PubMed Publications
 AP1S1 recombinant protein  >1 publications with AP1S2 and AP1S1
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