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APEX2 cdna clone

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Catalog # MBS1266384
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
APEX2 cdna clone
Product Name

APEX2, cDNA Clone

Popular Item
Full Product Name

APEX2 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgttgcgcg tggtgagctg gaacatcaat gggattcgga gacccctgca aggggtggca aatcaggaac ccagcaactg tgccgccgtg gccgtggggc gcattttgga cgagctggat gcggatatcg tctgtctcca ggaaaccaaa gtgaccaggg atgcactgac agagcccctg gctatcgttg agggttataa ctcctatttc agcttcagcc gcaaccgtag cggctattct ggtgtagcca ccttctgtaa ggacaatgct accccagtgg ctgctgaaga aggcctgagt ggcctgtttg ccacccagaa tggggatgtt ggttgctatg gaaacatgga tgagtttacc caagaggaac tccgggctct ggatagtgag ggcagggccc tcctcacaca gcataagatc cgcacatggg aaggtaagga gaagaccttg accctaatca acgtgtactg cccccatgcg gaccctggga ggcctgagcg gctagtcttt aagatgcgct tctatcgttt gctgcaaatc cgagcagaag ccctcctggc ggcaggcagc catgtgatca ttctgggtga cctgaataca gcccaccgcc ccattgacca ctgggatgca gtcaacctgg aatgctttga agaggaccca gggcgcaagt ggatggacag cttgctcagt aacttggggt gccagtctgc ctctcatgta gggcccttca tcgatagcta ccgctgcttc caaccaaagc aggagggggc cttcacctgc tggtcagcag tcactggcgc ccgccatctc aactatggct cccggcttga ctatgtgctg ggggacagga ccctggtcat agacaccttt caggcctctt tcctgctgcc tgaggtgatg ggctctgacc actgccctgt gggtgcagtc ttgagtgtgt cctctgtgcc tgcaaaacag tgcccacctc tgtgcacccg cttcctccct gagtttgcag gcacccagct caagatcctt cgcttcctag ttcctctcga acaaagtcct gtgttggagc agtcgacgct gcagcacaac aatcaaaccc gggtacagac atgccaaaac aaagcccaag tgcgctcaac caggcctcag cccagtcagg ttggctctag cagaggccag aaaaacctga agagctactt tcagccctcc cctagctgtc cccaagcctc tcctgacata gagctgccta gcctaccact gatgagcgcc ctcatgaccc cgaagactcc agaagagaag gcagtggcca aagtggtgaa ggggcaggcc aagacttcag aagccaaaga tgagaaggag ttacggacct cattctggaa gtctgtgctg gcggggccct tgcgcacacc cctctgtggg ggccacaggg agccatgtgt gatgcgtact gtgaagaagc caggacccaa cttgggccgc cgcttctaca tgtgtgccag gccccggggt cctcccactg acccctcctc ccggtgcaac ttcttcctct ggagcaggcc cagctga
OMIM
300773
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of APEX2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for APEX2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,401 Da
NCBI Official Full Name
Homo sapiens APEX nuclease (apurinic/apyrimidinic endonuclease) 2, mRNA
NCBI Official Synonym Full Names
apurinic/apyrimidinic endodeoxyribonuclease 2
NCBI Official Symbol
APEX2  [Similar Products]
NCBI Official Synonym Symbols
APE2; XTH2; ZGRF2; APEXL2
  [Similar Products]
NCBI Protein Information
DNA-(apurinic or apyrimidinic site) lyase 2
UniProt Protein Name
DNA-(apurinic or apyrimidinic site) lyase 2
UniProt Synonym Protein Names
AP endonuclease XTH2; APEX nuclease 2; APEX nuclease-like 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2
UniProt Gene Name
APEX2  [Similar Products]
UniProt Synonym Gene Names
APE2; APEXL2; XTH2; AP endonuclease 2  [Similar Products]
UniProt Entry Name
APEX2_HUMAN
NCBI Summary for APEX2
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for APEX2
APEX2: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes. Belongs to the DNA repair enzymes AP/ExoA family.

Protein type: EC 4.2.99.18; Lyase; Mitochondrial

Chromosomal Location of Human Ortholog: Xp11.21

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function: DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA specific 3'-5' exodeoxyribonuclease activity

Biological Process: base-excision repair
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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