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APH1B elisa kit :: Human anterior pharynx defective 1 homolog B (C. elegans) ELISA Kit

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Catalog # MBS9319659
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APH1B elisa kit
Product Name

anterior pharynx defective 1 homolog B (C. elegans) (APH1B), ELISA Kit

Full Product Name

Human Gamma-secretase subunit APH-1B, APH1B ELISA Kit

Product Synonym Names
Human Gamma-secretase subunit APH-1B (APH1B) ELISA kit; APH-1B; DKFZp564D0372; FLJ33115; PRO1328; PSFL; TAAV688; anterior pharynx defective 1B-like; presenilin stabilization factor-like; anterior pharynx defective 1 homolog B (C. elegans)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
607630
3D Structure
ModBase 3D Structure for Q8WW43
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of APH1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for APH1Bpurchase
MBS9319659 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the anterior pharynx defective 1 homolog B (C. elegans) (APH1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing APH1B. The ELISA analytical biochemical technique of the MBS9319659 kit is based on APH1B antibody-APH1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect APH1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, APH1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for APH1B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,460 Da
NCBI Official Full Name
gamma-secretase subunit APH-1B isoform 2
NCBI Official Synonym Full Names
APH1B gamma secretase subunit
NCBI Official Symbol
APH1B  [Similar Products]
NCBI Official Synonym Symbols
PSFL; APH-1B; PRO1328; TAAV688
  [Similar Products]
NCBI Protein Information
gamma-secretase subunit APH-1B; aph-1beta; anterior pharynx defective 1 homolog B
UniProt Protein Name
Gamma-secretase subunit APH-1B
UniProt Synonym Protein Names
Aph-1beta; Presenilin-stabilization factor-like
Protein Family
UniProt Gene Name
APH1B  [Similar Products]
UniProt Synonym Gene Names
PSFL; UNQ688/PRO1328; APH-1b  [Similar Products]
UniProt Entry Name
APH1B_HUMAN
NCBI Summary for APH1B
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
UniProt Comments for APH1B
APH1B: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: transport vesicle; plasma membrane; integral to membrane

Molecular Function: peptidase activity; protein binding

Biological Process: positive regulation of catalytic activity; axon guidance; Notch signaling pathway; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; ephrin receptor signaling pathway; Notch receptor processing; protein processing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with APH1B elisa kit
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