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Apo CIII protein :: Apolipoprotein CIII (Apo CIII) Protein

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Catalog # MBS390135
Unit / Price
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  0.2 mg  /  $315 +1 FREE 8GB USB
  0.5 mg  /  $640 +1 FREE 8GB USB
  1 mg  /  $1,095 +1 FREE 8GB USB
Apo CIII protein
Product Name

Apolipoprotein CIII (Apo CIII), Protein

Popular Item
Full Product Name

Human Apolipoprotein CIII (Apo CIII)

Product Synonym Names
Human Apolipoprotein CIII (Apo CIII)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (116700624..116703787). Location: 11q23.3
OMIM
107720
3D Structure
ModBase 3D Structure for P02656
Purity/Purification
After series ultracentrifugations, Very Low Density Lipoprotein (VLDL) is isolated from human plasma. Apo CIII is purified from delepidated VLDL, followed by gel-filtration and DEAE-Sepharcyl chromatography. Minor impurities of other apo-poteins are then
Concentration
1 mg / ml, determined by the Lowry method (lot specific)
Source Note
From fresh human plasma that has tested negative for Hepatitis C, HIV-I and HIV-II antibodies as well as Hepatitis surface antigens.
Preservative
75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02 % NaN3, pH 7.4.
Preparation and Storage
-20 degree C for long-term storage, 2-8 degree C for short-term storage. Aliquot to avoid repeated freezing and thawing.
Other Notes
Small volumes of Apo CIII protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Apo CIII protein
Applications Tested/Suitable for Apo CIII protein
SDS-PAGE
Application Notes for Apo CIII protein
Purity > 98% by SDS-PAGE.
NCBI/Uniprot data below describe general gene information for Apo CIII. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,852 Da
NCBI Official Full Name
apolipoprotein C-III
NCBI Official Synonym Full Names
apolipoprotein C-III
NCBI Official Symbol
APOC3  [Similar Products]
NCBI Official Synonym Symbols
HALP2; APOCIII
  [Similar Products]
NCBI Protein Information
apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3
UniProt Protein Name
Apolipoprotein C-III
UniProt Synonym Protein Names
Apolipoprotein C3
UniProt Gene Name
APOC3  [Similar Products]
UniProt Synonym Gene Names
Apo-CIII; ApoC-III  [Similar Products]
UniProt Entry Name
APOC3_HUMAN
NCBI Summary for Apo CIII
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
UniProt Comments for Apo CIII
Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular location: Secreted.

Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Post-translational modification: The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.11 Ref.12

Involvement in disease: Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Sequence similarities: Belongs to the apolipoprotein C3 family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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