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APOC3 antigen :: Apolipoprotein CIII Antigen

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Catalog # MBS568805
Unit / Price
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  0.2 mg  /  $495 +1 FREE 8GB USB
APOC3 antigen
Product Name

Apolipoprotein CIII (APOC3), Antigen

Full Product Name

Apolipoprotein CIII Antigen >95%

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
107720
Host
Human Plasma
Purity/Purification
>=95% by SDS-PAGE
Form/Format
Lyophilized from 10 mM Ammonia Bicarbonate, pH 7.4
Preparation and Storage
Store at <=-20 degree C
Other Notes
Small volumes of APOC3 antigen vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for APOC3 antigen
Applications Tested/Suitable for APOC3 antigen
Immunogen Grade
NCBI/Uniprot data below describe general gene information for APOC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,852 Da[Similar Products]
NCBI Official Full Name
apolipoprotein C-III
NCBI Official Synonym Full Names
apolipoprotein C3
NCBI Official Symbol
APOC3  [Similar Products]
NCBI Official Synonym Symbols
HALP2; APOCIII
  [Similar Products]
NCBI Protein Information
apolipoprotein C-III
UniProt Protein Name
Apolipoprotein C-III
UniProt Synonym Protein Names
Apolipoprotein C3
Protein Family
UniProt Gene Name
APOC3  [Similar Products]
UniProt Synonym Gene Names
Apo-CIII; ApoC-III  [Similar Products]
UniProt Entry Name
APOC3_HUMAN
NCBI Summary for APOC3
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
UniProt Comments for APOC3
APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family.

Protein type: Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: chylomicron; early endosome; extracellular region; extracellular space

Molecular Function: cholesterol binding; enzyme regulator activity; lipase inhibitor activity; phospholipid binding

Biological Process: cholesterol efflux; cholesterol homeostasis; G-protein coupled receptor protein signaling pathway; inflammatory response; lipoprotein metabolic process; lipoprotein transport; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; regulation of Cdc42 protein signal transduction; response to peptide hormone stimulus; response to triglyceride; response to vitamin A; retinoid metabolic process; reverse cholesterol transport; triacylglycerol catabolic process; triacylglycerol metabolic process

Disease: Apolipoprotein C-iii Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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