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APOC3 native protein :: Apolipoprotein CIII (Apo CIII) Native Protein

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Catalog # MBS318091
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
APOC3 native protein
Product Name

Apolipoprotein CIII (Apo CIII) (APOC3), Native Protein

Popular Item
Also Known As

Human Apolipoprotein CIII

Product Synonym Names
Human Apolipoprotein CIII (Apo CIII)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
99
Chromosome Location
Chromosome: 11; NC_000011.9 (116700624..116703787). Location: 11q23.1-q23.2
OMIM
107720
3D Structure
ModBase 3D Structure for P02656
Host
Human plasma, Very Low Density Lipoprotein (VLDL)
Specificity
Apolipoprotein CIII (Apo CIII)
Purity/Purification
>=95% pure (SDS-PAGE)
Form/Format
Purified, Lyophilized
Reconstitute with 59.9ul distilled water.
Concentration
1.67mg/ml (prior to lyophilization) (lot specific)
Inactivation
Not applicable
Buffer
Lyophilized from 10mM NH4HCO3, pH 7.4
Preservative
No
Lyophilized
Yes
Warnings
All human source materials have tested non-reactive for HBsAg, anti-HCV, anti-HBc and negative for anti-HIV 1 and HIV 2 by FDA required tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids o
Preparation and Storage
Store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of APOC3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for APOC3 native protein
NCBI/Uniprot data below describe general gene information for APOC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,852 Da[Similar Products]
NCBI Official Full Name
apolipoprotein C-III
NCBI Official Synonym Full Names
apolipoprotein C-III
NCBI Official Symbol
APOC3  [Similar Products]
NCBI Official Synonym Symbols
APOCIII; MGC150353
  [Similar Products]
NCBI Protein Information
apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353
UniProt Protein Name
Apolipoprotein C-III
UniProt Synonym Protein Names
Apolipoprotein C3
Protein Family
UniProt Gene Name
APOC3  [Similar Products]
UniProt Entry Name
APOC3_HUMAN
NCBI Summary for APOC3
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]
UniProt Comments for APOC3
Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular location: Secreted.

Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Post-translational modification: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.9 Ref.10

Involvement in disease: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [

MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Ref.11

Sequence similarities: Belongs to the apolipoprotein C3 family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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