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ARAF blocking peptide :: A-RAF Blocking Peptide

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Catalog # MBS8243442
Unit / Price
  1 mg  /  $160 +1 FREE 8GB USB
  5 mg  /  $305 +1 FREE 8GB USB
ARAF blocking peptide
Product Name

A-RAF (ARAF), Blocking Peptide

Also Known As

A-RAF Blocking Peptide

Product Synonym Names
ARAF1; PKS; PKS2; Serine/threonine-protein kinase A-Raf; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks
Antibody/Peptide Pairs
A-RAF peptide (MBS8243442) is used for blocking the activity of A-RAF antibody (MBS8243053)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
606
OMIM
311010
3D Structure
ModBase 3D Structure for P10398
Host
Synthetic
Species Reactivity
Human
Purity/Purification
>85%
Form/Format
Lyophilized Powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of ARAF blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ARAF blocking peptide
The peptide is used to block Anti-A-RAF Antibody reactivity.
Applications Tested/Suitable for ARAF blocking peptide
Blocking (BL)
Application Notes for ARAF blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for ARAF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,904 Da
NCBI Official Full Name
Serine/threonine-protein kinase A-Raf
NCBI Official Synonym Full Names
A-Raf proto-oncogene, serine/threonine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
PKS2; A-RAF; ARAF1; RAFA1
  [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase A-Raf
UniProt Protein Name
Serine/threonine-protein kinase A-Raf
UniProt Synonym Protein Names
Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks
UniProt Gene Name
UniProt Synonym Gene Names
ARAF1; PKS; PKS2  [Similar Products]
UniProt Entry Name
ARAF_HUMAN
NCBI Summary for ARAF
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
UniProt Comments for ARAF
ARAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.

Protein type: Kinase, protein; Protein kinase, TKL; Oncoprotein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family

Chromosomal Location of Human Ortholog: Xp11.4-p11.2

Cellular Component: cytosol

Molecular Function: ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein activity

Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein modification process; Ras protein signal transduction; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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