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ARFGEF2 elisa kit :: Human ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) ELISA Kit

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Catalog # MBS9331291
Unit / Price
  48-Strip-Wells  /  $470 +1 FREE 8GB USB
  96-Strip-Wells  /  $680 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
  10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
ARFGEF2 elisa kit
Product Name

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ARFGEF2), ELISA Kit

Full Product Name

Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2, ARFGEF2 ELISA Kit

Product Synonym Names
Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) ELISA kit; BIG2; FLJ23723; PVNH2; dJ1164I10.1; ADP-ribosylation factor guanine nucleotide-exchange factor 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 608097
3D Structure
ModBase 3D Structure for Q9Y6D5
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of ARFGEF2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forARFGEF2purchase
MBS9331291 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ARFGEF2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ARFGEF2. The ELISA analytical biochemical technique of the MBS9331291 kit is based on ARFGEF2 antibody-ARFGEF2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARFGEF2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARFGEF2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for ARFGEF2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
202,038 Da
NCBI Official Full Name
brefeldin A-inhibited guanine nucleotide-exchange protein 2
NCBI Official Synonym Full Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
NCBI Official Symbol
ARFGEF2  [Similar Products]
NCBI Official Synonym Symbols
BIG2; PVNH2; dJ1164I10.1
  [Similar Products]
NCBI Protein Information
brefeldin A-inhibited guanine nucleotide-exchange protein 2; brefeldin A-inhibited GEP 2
UniProt Protein Name
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
UniProt Synonym Protein Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2
UniProt Gene Name
ARFGEF2  [Similar Products]
UniProt Synonym Gene Names
ARFGEP2; BIG2; Brefeldin A-inhibited GEP 2  [Similar Products]
UniProt Entry Name
BIG2_HUMAN
NCBI Summary for ARFGEF2
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
UniProt Comments for ARFGEF2
ARFGEF2: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Defects in ARFGEF2 are the cause of autosomal recessive periventricular nodular heterotopia type 2 (PVNH2); also known as periventricular heterotopia with microcephaly autosomal recessive. PVNH is a developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH2 is an autosomal recessive form characterized by microcephaly (small brain), severe developmental delay and recurrent infections. No anomalies extrinsic to the central nervous system, such as dysmorphic features or grossly abnormal endocrine or other conditions, are associated with PVNH2.

Protein type: GEFs, ARF; GEFs

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: asymmetric synapse; Golgi membrane; recycling endosome; membrane; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; dendritic spine; microtubule organizing center; cytoplasmic vesicle; trans-Golgi network; cytosol; cell junction

Molecular Function: protein binding; myosin binding; guanyl-nucleotide exchange factor activity; GABA receptor binding; ARF guanyl-nucleotide exchange factor activity

Biological Process: vesicle-mediated transport; receptor recycling; Golgi to plasma membrane transport; protein transport; exocytosis; endosome organization and biogenesis; endomembrane organization; regulation of ARF protein signal transduction; positive regulation of tumor necrosis factor production; positive regulation of GTPase activity

Disease: Periventricular Heterotopia With Microcephaly, Autosomal Recessive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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