NP_006411.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
202,038 Da
NCBI Official Full Name
brefeldin A-inhibited guanine nucleotide-exchange protein 2
NCBI Official Synonym Full Names
ADP ribosylation factor guanine nucleotide exchange factor 2
NCBI Protein Information
brefeldin A-inhibited guanine nucleotide-exchange protein 2
UniProt Protein Name
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
UniProt Synonym Protein Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2
UniProt Synonym Gene Names
NCBI Summary for ARFGEF2
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
UniProt Comments for ARFGEF2
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
Product References and Citations for anti-ARFGEF2 antibody
Togawa A., J. Biol. Chem. 274:12308-12315(1999). Deloukas P., Nature 414:865-871(2001). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Research Articles on ARFGEF2
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Products associated with anti-ARFGEF2 antibody
Pathways associated with anti-ARFGEF2 antibody
Diseases associated with anti-ARFGEF2 antibody
Organs/Tissues associated with anti-ARFGEF2 antibody
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