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ARHGDIA recombinant protein :: Rho GDP-dissociation inhibitor 1 (ARHGDIA) Recombinant Protein

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Catalog # MBS967690
Unit / Price
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  0.05 mg (E-Coli)  /  $600 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $730 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $805 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $890 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $970 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $990 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,120 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,205 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,335 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,390 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,780 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,820 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,965 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,830 +3 FREE 8GB USB
ARHGDIA recombinant protein
Product Name

Rho GDP-dissociation inhibitor 1 (ARHGDIA), Recombinant Protein

Full Product Name

Recombinant Human Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-204aa, Full Length of Mature Protein
Sequence
AEQEPTAEQL AQIAAENEED EHSVNYKPPA QKSIQEIQEL DKDDESLRKY KEALLGRVAV SADPNVPNVV VTGLTLVCSS APGPLELDLT GDLESFKKQS FVLKEGVEYR IKISFRVNRE IVSGMKYIQH TYRKGVKIDK TDYMVGSYGP RAEEYEFLTP VEEAPKGMLA RGSYSIKSRF TDDDKTDHLS WEWNLTIKKD WKD
OMIM
601925
3D Structure
ModBase 3D Structure for P52565
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ARHGDIA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ARHGDIA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,233 Da
NCBI Official Full Name
rho GDP-dissociation inhibitor 1 isoform a
NCBI Official Synonym Full Names
Rho GDP dissociation inhibitor alpha
NCBI Official Symbol
ARHGDIA  [Similar Products]
NCBI Official Synonym Symbols
GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e
  [Similar Products]
NCBI Protein Information
rho GDP-dissociation inhibitor 1
UniProt Protein Name
Rho GDP-dissociation inhibitor 1
UniProt Synonym Protein Names
Rho-GDI alpha
UniProt Gene Name
ARHGDIA  [Similar Products]
UniProt Synonym Gene Names
GDIA1; Rho GDI 1  [Similar Products]
NCBI Summary for ARHGDIA
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for ARHGDIA
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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