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ARHGEF10 cdna clone

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Catalog # MBS1268950
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
ARHGEF10 cdna clone
Product Name

ARHGEF10, cDNA Clone

Popular Item
Also Known As

ARHGEF10 cDNA Clone

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
1143
Sequence
atggagaatc cagaagaagc aatttacgat gacgttccaa gggaaaactc agactctgaa ccagatgaaa tgatttatga tgatgttgag aatggggatg aaggtggaaa cagctccttg gaatacggat ggagttcgag tgaatttgaa agttacgaag agcagagtga ctcggagtgc aagaatggga ttcccaggtc cttcctgcgc agcaaccaca aaaagcaaat gcagaagctc gtgaaggccg cgaaggacgg caccaaggac gggctggaga ggaccagggc agccgtgaag aggggccgct ccttcatcag gaccaagtct ctcatcgcac aggatcacag atcttctctt gaggaagaac agaatttgtt cattgatgtt gactgcaagc acccggaagc catcttgacc ccgatgcccg agggtttatc tcagcagcag gttgtaagaa gatatatact gggttcagtt gtcgacagtg aaaagaacta cgtagatgct cttaagagga ttttggagca atatgagaag ccgctgtctg agatggagcc aaaggttctg agtgagagga agctgaagac ggtgttctac cgagtcaaag agatcctgca gtgccactcg ctatttcaga tcgcgctggc cagccgcgtt tccgagtggg actccgtgga aatgataggc gttgtcttcg tggcttcgtt ttctaagtcc atggtgctgg atgcatacag tgaatatgtg aacaatttca gcacagccgt ggcagtcctc aagaaaacat gtgccacaaa gcccgctttt cttgaatttt taaagcagga acaggaggcc agccccgatc gaaccacgct ctacagcctg atgatgaagc ccatccagag gttcccacag ttcatcctcc tgctccagga catgctgaag aacacctcca aaggccaccc cgacaggctg cctcttcaga tggccctgac agagctcgaa acactagcag agaagttaaa tgaaagaaag agagatgctg atcaacgctg tgaagtgaag caaatagcca aagccataaa cgaaagatac ctgaacaagg ttgagagagg ttttcttcaa ctctattcca aaattatttt tgctttgtgc taa
OMIM
608136
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ARHGEF10 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ARHGEF10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
148,869 Da
NCBI Official Full Name
Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10, mRNA
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 10
NCBI Official Symbol
ARHGEF10  [Similar Products]
NCBI Official Synonym Symbols
SNCV; GEF10
  [Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 10
UniProt Protein Name
Rho guanine nucleotide exchange factor 10
UniProt Gene Name
ARHGEF10  [Similar Products]
UniProt Synonym Gene Names
KIAA0294  [Similar Products]
UniProt Entry Name
ARHGA_HUMAN
NCBI Summary for ARHGEF10
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for ARHGEF10
ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: centrosome

Molecular Function: kinesin binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: centrosome duplication; myelination in the peripheral nervous system; positive regulation of stress fiber formation

Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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