NP_055444.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
151,612 Da
NCBI Official Full Name
rho guanine nucleotide exchange factor 10
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor (GEF) 10
NCBI Official Synonym Symbols
NCBI Protein Information
rho guanine nucleotide exchange factor 10
UniProt Protein Name
Rho guanine nucleotide exchange factor 10
UniProt Synonym Gene Names
UniProt Entry Name
ARHGA_HUMAN
NCBI Summary for ARHGEF10
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF10
ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; GEFs
Chromosomal Location of Human Ortholog: 8p23
Cellular Component: centrosome; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; kinesin binding
Biological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous system
Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant
Research Articles on ARHGEF10
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Pathways associated with ARHGEF10 elisa kit
Diseases associated with ARHGEF10 elisa kit
Organs/Tissues associated with ARHGEF10 elisa kit
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