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anti-ARHGEF11 antibody :: ARHGEF11 Antibody

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Catalog # MBS854235
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ARHGEF11, Antibody

Popular Item
Also Known As

ARHGEF11 Antibody

Product Synonym Names
ARHGB; glutamate transporter EAAT4-associated protein 48; GTRAP48; PDZ-RhoGEF; rho guanine exchange factor (GEF) 11; rhoA-specific guanine nucleotide exchange factor; rhoGEF glutamate transport modulator
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1522
OMIM
605708
3D Structure
ModBase 3D Structure for O15085
Species Reactivity
Human, Mouse, Rat
Specificity
ARHGEF11 antibody detects endogenous levels of total ARHGEF11 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human ARHGEF11.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ARHGEF11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ARHGEF11 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ARHGEF11 antibody
WB: 1:500~1:1000
ELISA: 1:5000

Western Blot (WB) of anti-ARHGEF11 antibody
Western blot analysis of extracts from A549 cells and COLO 205 cells, using ARHGEF11 antibody.
anti-ARHGEF11 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ARHGEF11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
172,244 Da
NCBI Official Full Name
rho guanine nucleotide exchange factor 11 isoform 1
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 11
NCBI Official Symbol
ARHGEF11  [Similar Products]
NCBI Official Synonym Symbols
GTRAP48; PDZ-RHOGEF
  [Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 11
UniProt Protein Name
Rho guanine nucleotide exchange factor 11
UniProt Synonym Protein Names
PDZ-RhoGEF
UniProt Gene Name
ARHGEF11  [Similar Products]
UniProt Synonym Gene Names
KIAA0380  [Similar Products]
NCBI Summary for ARHGEF11
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF11
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Product References and Citations for anti-ARHGEF11 antibody
Nagase T., DNA Res. 4:141-150(1997). Gregory S.G., Nature 441:315-321(2006). Ruemenapp U., FEBS Lett. 459:313-318(1999).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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