BC010046
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,056 Da
NCBI Official Full Name
Homo sapiens Rho guanine nucleotide exchange factor (GEF) 5, mRNA
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 5
NCBI Protein Information
rho guanine nucleotide exchange factor 5
UniProt Protein Name
Rho guanine nucleotide exchange factor 5
UniProt Synonym Protein Names
Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM
UniProt Synonym Gene Names
UniProt Entry Name
ARHG5_HUMAN
NCBI Summary for ARHGEF5
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF5
ARHGEF5: 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane
Molecular Function: GTP binding; guanyl-nucleotide exchange factor activity; protein binding
Biological Process: positive regulation of JNK activity; positive regulation of stress fiber formation; positive regulation of transcription factor activity; regulation of actin cytoskeleton organization and biogenesis; regulation of cytoskeleton organization and biogenesis; regulation of GTPase activity
Research Articles on ARHGEF5
Precautions
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Pathways associated with ARHGEF5 cdna clone
Diseases associated with ARHGEF5 cdna clone
Organs/Tissues associated with ARHGEF5 cdna clone
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