NP_001169.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,136 Da
NCBI Official Full Name
aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
NCBI Official Synonym Full Names
aryl hydrocarbon receptor nuclear translocator like
NCBI Official Synonym Symbols
TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5 [Similar Products]
NCBI Protein Information
aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProt Protein Name
Aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProt Synonym Protein Names
Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3
UniProt Synonym Gene Names
NCBI Summary for ARNTL
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for ARNTL
BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11p15.3
Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus; PML body; transcription factor complex
Molecular Function: aryl hydrocarbon receptor binding; bHLH transcription factor binding; DNA binding; Hsp90 protein binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding
Biological Process: circadian regulation of gene expression; circadian rhythm; maternal process involved in parturition; negative regulation of fat cell differentiation; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of TOR signaling; negative regulation of transcription, DNA-dependent; oxidative stress-induced premature senescence; positive regulation of canonical Wnt signaling pathway; positive regulation of circadian rhythm; positive regulation of protein acetylation; positive regulation of skeletal muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; proteasomal ubiquitin-dependent protein catabolic process; protein import into nucleus, translocation; regulation of cell cycle; regulation of cellular senescence; regulation of hair cycle; regulation of insulin secretion; regulation of neurogenesis; regulation of protein catabolic process; regulation of transcription, DNA-templated; regulation of type B pancreatic cell development; response to redox state; spermatogenesis; transcription from RNA polymerase II promoter
Research Articles on ARNTL
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Pathways associated with ARNTL elisa kit
Diseases associated with ARNTL elisa kit
Organs/Tissues associated with ARNTL elisa kit
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