NP_065733.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,748 Da
NCBI Official Full Name
arsenite methyltransferase
NCBI Official Synonym Full Names
arsenic (+3 oxidation state) methyltransferase
NCBI Protein Information
arsenite methyltransferase; methyltransferase cyt19; methylarsonite methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
UniProt Protein Name
Arsenite methyltransferase
UniProt Synonym Protein Names
Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
AS3MT_HUMAN
NCBI Summary for AS3MT
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
UniProt Comments for AS3MT
AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.
Protein type: Mitochondrial; EC 2.1.1.137; Methyltransferase
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: mitochondrion; cytoplasm; cytosol
Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: methylation; arsonoacetate metabolic process; toxin metabolic process
Research Articles on AS3MT
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Products associated with AS3MT elisa kit
Pathways associated with AS3MT elisa kit
Diseases associated with AS3MT elisa kit
Organs/Tissues associated with AS3MT elisa kit
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