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ASMT recombinant protein :: Acetylserotonin O-Methyltransferase Recombinant Protein

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Catalog # MBS146490
Unit / Price
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  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $3,515 +4 FREE 8GB USB
ASMT recombinant protein
Product Name

Acetylserotonin O-Methyltransferase (ASMT), Recombinant Protein

Full Product Name

Recombinant Human Acetylserotonin O-Methyltransferase

Product Synonym Names
ASMT Human; Acetylserotonin O-Methyltransferase Human Recombinant; HIOMT; HIOMTY; Acetylserotonin O-methyltransferase; Hydroxyindole O-methyltransferase; ASMT
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF PLMCDLGGDF FKDPLPEADL YILARVLHDW ADGKCSHLLE RIYHTCKPGG GILVIESLLD EDRRGPLLTQ LYSLNMLVQT EGQERTPTHY HMLLSSAGFR DFQFKKTGAI YDAILARK
OMIM
300015
3D Structure
ModBase 3D Structure for P46597
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The ASMT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol.
Sterile Filtered clear solution.
Other Notes
Small volumes of ASMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ASMT recombinant protein
Description: ASMT Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 318 amino acids (1-298 a.a) and having a molecular mass of 35.3kDa.ASMT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: ASMT is a member of the methyltransferase superfamily. ASMT participates in melatonin biosynthesis. ASMT Expressed in brain, retina and pineal gland, ASMT utilities to catalyze the final reaction in the synthesis of melatonin, particularly the conversion of S-adenosyl-L-methionine and N-acetylserotonin to S-adenosyl-Lhomocysteine and melatonin.
NCBI/Uniprot data below describe general gene information for ASMT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,661 Da
NCBI Official Full Name
acetylserotonin O-methyltransferase isoform 1
NCBI Official Synonym Full Names
acetylserotonin O-methyltransferase
NCBI Official Symbol
NCBI Official Synonym Symbols
ASMTY; HIOMT; HIOMTY
  [Similar Products]
NCBI Protein Information
acetylserotonin O-methyltransferase; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome); hydroxyindole O-methyltransferase
UniProt Protein Name
Acetylserotonin O-methyltransferase
UniProt Synonym Protein Names
Hydroxyindole O-methyltransferase; HIOMT
UniProt Gene Name
UniProt Synonym Gene Names
HIOMT  [Similar Products]
UniProt Entry Name
ASMT_HUMAN
NCBI Summary for ASMT
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
UniProt Comments for ASMT
ASMT: Produces melatonin (N-acetyl-5-methoxytryptamine) from N-acetylserotonin. Belongs to the methyltransferase superfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.4; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3

Cellular Component: cytosol

Molecular Function: identical protein binding; protein homodimerization activity; O-methyltransferase activity; acetylserotonin O-methyltransferase activity

Biological Process: methylation; melatonin biosynthetic process; translation; indolalkylamine biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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