NP_036636.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,054 Da
NCBI Official Full Name
sodium/potassium-transporting ATPase subunit alpha-1
NCBI Official Synonym Full Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
sodium/potassium-transporting ATPase subunit alpha-1
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit alpha-1
UniProt Synonym Protein Names
Sodium pump subunit alpha-1
UniProt Synonym Gene Names
UniProt Entry Name
AT1A1_RAT
NCBI Summary for ATP1A1
mediates Na+ and K+ transport; may play a role in regulation of blood pressure [RGD, Feb 2006]
UniProt Comments for ATP1A1
ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described.
Protein type: Transporter; Membrane protein, multi-pass; EC 3.6.3.9; Hydrolase; Transporter, ion channel; Membrane protein, integral
Cellular Component: Golgi apparatus; protein complex; endoplasmic reticulum; basolateral plasma membrane; T-tubule; integral to membrane; caveola; lipid raft; membrane; apical plasma membrane; plasma membrane; melanosome; sodium:potassium-exchanging ATPase complex; endosome; myelin sheath; vesicle; sarcolemma
Molecular Function: potassium ion binding; protein domain specific binding; protein binding; sodium ion binding; chaperone binding; phosphoric monoester hydrolase activity; sodium:potassium-exchanging ATPase activity; phosphoinositide 3-kinase binding; ankyrin binding; ADP binding; protein kinase binding; ATP binding
Biological Process: response to drug; cellular sodium ion homeostasis; negative regulation of heart contraction; membrane hyperpolarization; sodium ion transport; positive regulation of striated muscle contraction; regulation of sodium ion transport; cellular potassium ion homeostasis; negative regulation of glucocorticoid biosynthetic process; potassium ion import; dephosphorylation; energy coupled proton transport, against electrochemical gradient; regulation of blood pressure; positive regulation of heart contraction; potassium ion transport; regulation of the force of heart contraction; cardiac muscle contraction
Research Articles on ATP1A1
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Products associated with ATP1A1 sirna
Pathways associated with ATP1A1 sirna
Diseases associated with ATP1A1 sirna
Organs/Tissues associated with ATP1A1 sirna
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