NP_001668.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,893 Da
NCBI Official Full Name
sodium/potassium-transporting ATPase subunit beta-1
NCBI Official Synonym Full Names
ATPase, Na+/K+ transporting, beta 1 polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
sodium/potassium-transporting ATPase subunit beta-1; Beta 1-subunit of Na(+),K(+)-ATPase; Na, K-ATPase beta-1 polypeptide; adenosinetriphosphatase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium-dependent ATPase beta-1 subunit; sodium/potassium-transporting ATPase beta-1 chain
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit beta-1
UniProt Synonym Protein Names
Sodium/potassium-dependent ATPase subunit beta-1
UniProt Synonym Gene Names
UniProt Entry Name
AT1B1_HUMAN
NCBI Summary for ATP1B1
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
UniProt Comments for ATP1B1
ATP1B1: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 1q24
Cellular Component: basolateral plasma membrane; apical plasma membrane; plasma membrane; caveola; sodium:potassium-exchanging ATPase complex; sarcolemma; vesicle
Molecular Function: protein binding; ATPase activator activity; sodium:potassium-exchanging ATPase activity; ATPase binding
Biological Process: cellular sodium ion homeostasis; protein stabilization; cellular potassium ion homeostasis; cellular calcium ion homeostasis; potassium ion import; positive regulation of ATPase activity; regulation of gene expression; response to hypoxia; blood coagulation; cell adhesion; leukocyte migration; transmembrane transport; cardiac muscle contraction
Disease: Hypertension, Essential
Research Articles on ATP1B1
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Products associated with ATP1B1 recombinant protein
Pathways associated with ATP1B1 recombinant protein
Diseases associated with ATP1B1 recombinant protein
Organs/Tissues associated with ATP1B1 recombinant protein
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