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ATP2A2 elisa kit :: Canine Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) ELISA Kit

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Catalog # MBS7215782
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ATP2A2 elisa kit
Product Name

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit

Full Product Name

Canine Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 124200
Species Reactivity
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of ATP2A2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for ATP2A2purchase
MBS7215782 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ATP2A2. The ELISA analytical biochemical technique of the MBS7215782 kit is based on ATP2A2 antibody-ATP2A2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATP2A2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATP2A2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for ATP2A2 elisa kit
NCBI/Uniprot data below describe general gene information for ATP2A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
109,734 Da
NCBI Official Full Name
sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b
NCBI Official Synonym Full Names
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
NCBI Official Symbol
ATP2A2  [Similar Products]
NCBI Official Synonym Symbols
DD; DAR; ATP2B; SERCA2
  [Similar Products]
NCBI Protein Information
sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; SR Ca(2+)-ATPase 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
UniProt Protein Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
UniProt Synonym Protein Names
Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
UniProt Gene Name
ATP2A2  [Similar Products]
UniProt Synonym Gene Names
ATP2B; SERCA2; SR Ca(2+)-ATPase 2  [Similar Products]
UniProt Entry Name
AT2A2_HUMAN
NCBI Summary for ATP2A2
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
UniProt Comments for ATP2A2
SERCA2: an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described.

Protein type: Endoplasmic reticulum; Transporter, ion channel; Membrane protein, integral; Transporter; Cell adhesion; EC 3.6.3.8; Hydrolase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; sarcoplasmic reticulum; membrane; endoplasmic reticulum; integral to plasma membrane

Molecular Function: protein C-terminus binding; protein binding; enzyme binding; calcium-transporting ATPase activity; metal ion binding; calcium ion binding; ATP binding

Biological Process: cellular calcium ion homeostasis; ER-nuclear signaling pathway; epidermis development; endoplasmic reticulum calcium ion homeostasis; negative regulation of heart contraction; metabolic process; elevation of endoplasmic reticulum calcium ion concentration; positive regulation of heart rate; blood coagulation; cell adhesion; transmembrane transport; regulation of the force of heart contraction

Disease: Acrokeratosis Verruciformis; Darier-white Disease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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