NP_569055.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,362 Da
NCBI Official Full Name
ATR-interacting protein isoform 1
NCBI Official Synonym Full Names
ATR interacting protein
NCBI Protein Information
ATR-interacting protein; ATM and Rad3-related-interacting protein
UniProt Protein Name
ATR-interacting protein
UniProt Synonym Protein Names
ATM and Rad3-related-interacting protein
UniProt Synonym Gene Names
UniProt Entry Name
ATRIP_HUMAN
NCBI Summary for ATRIP
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
UniProt Comments for ATRIP
ATRIP: is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Heterodimerizes with ATR. The heterodimer binds replication protein A (RPA), a protein complex that subsequently is recruited to single stranded DNA (ssDNA). Its EEXXXDDL motif is required for the interaction with catalytic subunit of DNA-PK and its recruitment to sites of DNA damage. e for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. Three alternatively spliced human isoforms have been reported.
Protein type: DNA-binding; DNA repair, damage; Cell cycle regulation
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: DNA damage checkpoint; DNA repair; DNA replication
Research Articles on ATRIP
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Pathways associated with ATRIP elisa kit
Diseases associated with ATRIP elisa kit
Organs/Tissues associated with ATRIP elisa kit
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