• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-AurB/C antibody :: AurB/C Antibody

Scan QR to view Datasheet
Catalog # MBS853107
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

AurB/C, Antibody

Popular Item
Also Known As

AurB/C (Phospho-Thr236/202) Antibody

Product Synonym Names
AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 1; Aurora/Ipl1/Eg2 protein 2; EC 2.7.11.1; STK13; STKD; Serine/threonine protein kinase 13; kinase AIK3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
309
OMIM
243060
3D Structure
ModBase 3D Structure for Q9UQB9
Species Reactivity
Human, Mouse, Rat
Specificity
AurB/C (Phospho-Thr236/202) antibody detects endogenous levels of AurB/C only when phosphorylated at threonine 236/202.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 236/202 (C-G-TP-L-D).
All Sites
Human: Thr236/202
Mouse: Thr241/175
Rat: Thr239/175
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-AurB/C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AurB/C antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-AurB/C antibody
IHC: 1:50-1:100
ELISA: 1:10000

Testing Data of anti-AurB/C antibody
P-peptide-+
anti-AurB/C antibody Testing Data image
Immunohistochemistry (IHC) of anti-AurB/C antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using AurB/C (Phospho-Thr236/202) antibody. AurB/C (Phospho-Thr236/202) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-AurB/C antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AurB/C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,672 Da
NCBI Official Full Name
aurora kinase C isoform 1
NCBI Official Synonym Full Names
aurora kinase C
NCBI Official Symbol
AURKC  [Similar Products]
NCBI Official Synonym Symbols
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
  [Similar Products]
NCBI Protein Information
aurora kinase C
UniProt Protein Name
Aurora kinase C
UniProt Synonym Protein Names
Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
UniProt Gene Name
AURKC  [Similar Products]
UniProt Synonym Gene Names
AIE2; AIK3; AIRK3; ARK3; STK13; ARK-3; Aurora-related kinase 3  [Similar Products]
NCBI Summary for AurB/C
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for AurB/C
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Product References and Citations for anti-AurB/C antibody
Steven L. Warner. Mol. Cancer Ther., Oct 2006; 5: 2450-2458. Adrianne E. Hontz. AACR Meeting Abstracts, Apr 2005; 2005: 492. Adrianne E. Hontz. AACR Meeting Abstracts, Apr 2006; 2006: 1326.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000