NP_001243763.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
aurora kinase B isoform 2
NCBI Official Synonym Full Names
aurora kinase B
NCBI Official Synonym Symbols
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2 [Similar Products]
NCBI Protein Information
aurora kinase B
UniProt Protein Name
Aurora kinase B
UniProt Synonym Protein Names
Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B
UniProt Synonym Gene Names
AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; AIM-1; ARK-2; Aurora-related kinase 2 [Similar Products]
NCBI Summary for AurB
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for AurB
AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.
Protein type: AUR family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: chromocenter; condensed chromosome, centromeric region; condensed nuclear chromosome, centromeric region; cytosol; kinetochore; midbody; mitotic spindle midzone; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function: ATP binding; histone serine kinase activity; kinase binding; metal ion binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process: abscission; aging; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; attachment of spindle microtubules to kinetochore; cell proliferation; cellular response to UV; histone modification; mitotic spindle midzone assembly; negative regulation of B cell apoptotic process; negative regulation of cytokinesis; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytokinesis; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein amino acid phosphorylation; protein autophosphorylation; protein localization to kinetochore; protein sumoylation; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of chromosome segregation; sister chromatid cohesion; spindle checkpoint; spindle organization and biogenesis
Research Articles on AurB
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Products associated with AurB elisa kit
Pathways associated with AurB elisa kit
Diseases associated with AurB elisa kit
Organs/Tissues associated with AurB elisa kit
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