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anti-AXL antibody :: Rabbit AXL (Phospho-Tyr691) Antibody

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Catalog # MBS001060
Unit / Price
  0.05 mL  /  $270 +1 FREE 8GB USB
  0.1 mL  /  $445 +1 FREE 8GB USB
Product Name

AXL (Phospho-Tyr691), Antibody

Popular Item
Also Known As

Rabbit AXL (Phospho-Tyr691) Antibody

Product Synonym Names
Adhesion-related kinase; ARK; AXL oncogene; EC 2.7.10.1; kinase AXL; Tyrosine-protein kinase receptor UFO precursor; UFO
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
885
Chromosome Location
Chromosome: 19; NC_000019.9 (41725108..41767671). Location: 19q13.1
OMIM
109135
3D Structure
ModBase 3D Structure for P30530
Host
Rabbit
Species Reactivity
Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
Specificity
AXL (Phospho-Tyr691) antibody detects endogenous levels of AXL only when phosphorylated at tyrosine 691.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human AXL around the phosphorylation site of tyrosine 691(K-I-YP-N-G).
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Preparation and Storage
Store at -20°C/1 year
Other Notes
Small volumes of anti-AXL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AXL antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-AXL antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000

Immunohistochemistry of anti-AXL antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using AXL (Phospho-Tyr691) antibody.
anti-AXL antibody Immunohistochemistry (IHC) image
Western blot of anti-AXL antibody
Western blot analysis of extracts from HUVEC cells, treated with EGF (200ng/ml, 15mins), using AXL (Phospho-Tyr691) antibody.
anti-AXL antibody Western blot image
NCBI/Uniprot data below describe general gene information for AXL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,336 Da
NCBI Official Full Name
tyrosine-protein kinase receptor UFO isoform 2
NCBI Official Synonym Full Names
AXL receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
UFO; JTK11
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NCBI Protein Information
tyrosine-protein kinase receptor UFO; AXL oncogene; oncogene AXL; AXL transforming sequence/gene
UniProt Protein Name
Tyrosine-protein kinase receptor UFO
UniProt Synonym Protein Names
AXL oncogene
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
UFO_HUMAN
NCBI Summary for AXL
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for AXL
AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Protein kinase, TK; TK group; Axl family

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding

Biological Process: forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; organ regeneration; peptidyl-tyrosine phosphorylation; cell maturation; neuron migration; vagina development; negative regulation of tumor necrosis factor production; signal transduction; phagocytosis; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; positive regulation of protein kinase B signaling cascade; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; blood vessel remodeling; spermatogenesis; negative regulation of neuron apoptosis; positive regulation of cytokine and chemokine mediated signaling pathway; inflammatory response; vascular endothelial growth factor receptor signaling pathway; apoptotic cell clearance; secretion by cell
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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