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Azin1 recombinant protein :: Antizyme inhibitor 1 (Azin1) Recombinant Protein

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Catalog # MBS1020106
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $865 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $940 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,160 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,170 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,270 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,690 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $1,935 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,195 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,285 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,285 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,390 +4 FREE 8GB USB
Azin1 recombinant protein
Product Name

Antizyme inhibitor 1 (Azin1), Recombinant Protein

Full Product Name

Recombinant Mouse Antizyme inhibitor 1 (Azin1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-448aa, Full length protein
Sequence
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK KHSQWQTVVA QIKPFYTVKC NSTPAVLEIL AALGTGFACS SKNEMALVQE LGVSPENIIF TSPCKQVSQI KYAAKVGVNI MTCDNEIELK KIARNHPNAK VLLHIATEDN IGGEDGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS ACKEYQVYVH ALSDARCVFD MAGEFGFTMN MLDIGGGFTG TEIQLEEVNH VISPLLDIYF PEGSGIQIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFSS GVEKNGSDEP AFVYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR PAIYFMMSFS DWYEMQDAGI TSDAMMKNFF FAPSCIQLSQ EDSFSTEA
3D Structure
ModBase 3D Structure for O35484
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Azin1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Azin1 recombinant protein
Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. This protein is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.
NCBI/Uniprot data below describe general gene information for Azin1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,549 Da
NCBI Official Full Name
antizyme inhibitor 1 isoform 1
NCBI Official Synonym Full Names
antizyme inhibitor 1
NCBI Official Symbol
Azin1  [Similar Products]
NCBI Official Synonym Symbols
AZI; Oazi; Oazin; 1700085L02Rik
  [Similar Products]
NCBI Protein Information
antizyme inhibitor 1
UniProt Protein Name
Antizyme inhibitor 1
UniProt Synonym Protein Names
Ornithine decarboxylase antizyme inhibitor
Protein Family
UniProt Gene Name
Azin1  [Similar Products]
UniProt Synonym Gene Names
Oazi; Oazin; AZI  [Similar Products]
NCBI Summary for Azin1
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
UniProt Comments for Azin1
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:10698696, PubMed:18062773, PubMed:18369191).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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