Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-b-Catenin (pY280) antibody :: Rabbit b-Catenin (pY280) Antibody Catalog # MBS462211 Unit / Price 0.1 mg / $285 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name b-Catenin (pY280), Antibody Full Product Name Rabbit anti Phosph-beta-Catenin (Tyr280) antibody Product Synonym Names Rabbit anti-beta-Catenin (pY280) Product Gene Name anti-b-Catenin (pY280) antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 16; NC_007127.5 (7435502..7458779, complement) 3D Structure ModBase 3D Structure for Q7ZU14 Host Rabbit Species Reactivity Human, Rat, Mouse, Chicken, Canine Specificity This antibody recognizes ~88 kDa of human beta-Catenin protein. It also reacts with mouse and rat. The other species are not tested. Purity/Purification The Rabbit IgG is purified by Site-specific Epitope Affinity Purification. Form/Format This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer Concentration Size: 100 ug/200 ul (lot specific) Antigen Preparation A synthetic peptide corresponding to the epitope EPYGL at the phosphorylation site Tyr280 of human beta-catenin. Positive Control HELA cell lysate Preparation and Storage The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. Other Notes Small volumes of anti-b-Catenin (pY280) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-b-Catenin (pY280) antibody Beta-catenin is a cytosolic, 88 kDa, 781 amino acid protein belongs to the beta-catenin family. The N-terminus domain, containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin (s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates beta-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280 etc. Phosphorylation of beta-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3beta activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3beta, allowing unphosphorylated beta-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis. Applications Tested/Suitable for anti-b-Catenin (pY280) antibody ELISA, Western Blot, Immunohistochemistry Application Notes for anti-b-Catenin (pY280) antibody Western Blot: 0.1-1 ug/mlELISA: 0.01-0.1 ug/mlImmunoprecipitation: 2-5 ug/mlImmunohistochemistry: 2-5 ug/ml Testing Data of anti-b-Catenin (pY280) antibody TOP NCBI/Uniprot data below describe general gene information for b-Catenin (pY280). It may not necessarily be applicable to this product. NCBI GI # 1125100 NCBI GeneID 30265 UniProt Primary Accession # Q7ZU14 [Other Products] UniProt Related Accession # Q7ZU14; Q90424[Other Products] Molecular Weight 88 kDa TOP NCBI Official Full Name b-catenin NCBI Official Synonym Full Names catenin (cadherin-associated protein), beta 1 NCBI Official Symbol ctnnb1 [Similar Products] NCBI Official Synonym Symbols ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01 [Similar Products] NCBI Protein Information catenin beta-1; beta-catenin UniProt Protein Name Catenin (Cadherin-associated protein), beta 1 UniProt Gene Name ctnnb1 [Similar Products] UniProt Entry Name Q7ZU14_DANRE TOP Product References and Citations for anti-b-Catenin (pY280) antibody Park, C.S. et al. (2004) J. Biol. Chem. 279:19592. Research Articles on b-Catenin (pY280) 1. maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with anti-b-Catenin (pY280) antibody Products by Pathway Pathway Diagram Adherens Junction Pathway antibodies Adherens Junction Pathway Diagram Adherens Junction Pathway antibodies Adherens Junction Pathway Diagram Adherens Junctions Interactions Pathway antibodies Adherens Junctions Interactions Pathway Diagram Androgen Receptor Signaling Pathway antibodies Androgen Receptor Signaling Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram Apoptotic Cleavage Of Cellular Proteins Pathway antibodies Apoptotic Cleavage Of Cellular Proteins Pathway Diagram Apoptotic Execution Phase Pathway antibodies Apoptotic Execution Phase Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram Beta-catenin Phosphorylation Cascade Pathway antibodies Beta-catenin Phosphorylation Cascade Pathway Diagram Diseases associated with anti-b-Catenin (pY280) antibody Disease Name Pubmed Publications Neoplasms Antibodies >5482 publications with b-Catenin (pY280) and Neoplasms Intestinal Neoplasms Antibodies >1764 publications with b-Catenin (pY280) and Intestinal Neoplasms Colorectal Neoplasms Antibodies >1705 publications with b-Catenin (pY280) and Colorectal Neoplasms Adenocarcinoma Antibodies >1286 publications with b-Catenin (pY280) and Adenocarcinoma Colonic Neoplasms Antibodies >997 publications with b-Catenin (pY280) and Colonic Neoplasms Adenoma Antibodies >680 publications with b-Catenin (pY280) and Adenoma Liver Neoplasms Antibodies >627 publications with b-Catenin (pY280) and Liver Neoplasms Liver Diseases Antibodies >590 publications with b-Catenin (pY280) and Liver Diseases Cell Transformation, Neoplastic Antibodies >555 publications with b-Catenin (pY280) and Cell Transformation, Neoplastic Breast Neoplasms Antibodies >521 publications with b-Catenin (pY280) and Breast Neoplasms Organs/Tissues associated with anti-b-Catenin (pY280) antibody Organ/Tissue Name Pubmed Publications Bone Antibodies >897 publications with b-Catenin (pY280) and Bone Brain Antibodies >789 publications with b-Catenin (pY280) and Brain Muscle Antibodies >585 publications with b-Catenin (pY280) and Muscle Kidney Antibodies >584 publications with b-Catenin (pY280) and Kidney Heart Antibodies >344 publications with b-Catenin (pY280) and Heart Eye Antibodies >264 publications with b-Catenin (pY280) and Eye Reproductive System Antibodies >111 publications with b-Catenin (pY280) and Reproductive System Inner Ear Antibodies >30 publications with b-Catenin (pY280) and Inner Ear Fin Antibodies >21 publications with b-Catenin (pY280) and Fin Whole Body Antibodies >20 publications with b-Catenin (pY280) and Whole Body TOP © 2006-18 MyBioSource.com. 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