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BAIAP2 cdna clone

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Catalog # MBS1267744
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $285 +1 FREE 8GB USB
BAIAP2 cdna clone
Product Name

BAIAP2, cDNA Clone

Full Product Name

BAIAP2 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtctctgt ctcgctcaga ggagatgcac cggctcacgg aaaatgtcta taagaccatc atggagcagt tcaaccctag cctccggaac ttcatcgcca tggggaagaa ttacgagaag gcactggcag gtgtgacgta tgcagccaaa ggctactttg acgccctggt gaagatgggg gagctggcca gcgagagcca gggctccaaa gaactcggag acgttctctt ccagatggct gaagtccaca ggcagatcca gaatcagctg gaagaaatgc tgaagtcttt tcacaacgag ctgcttacgc agctggagca gaaggtggag ctggactcca ggtatctgag tgctgcgctg aagaaatacc agactgagca aaggagcaaa ggcgacgccc tggacaagtg tcaggctgag ctgaagaagc ttcggaagaa gagccagggc agcaagaatc ctcagaagta ctcggacaag gagctgcagt acatcgacgc catcagcaac aagcagggcg agctggagaa ttacgtgtcc gacggctaca agaccgcact gacagaggag cgcaggcgct tctgcttcct ggtggagaag cagtgcgccg tggccaagaa ctccgcggcc taccactcca agggcaagga gctgctggcg cagaagctgc cgctgtggca acaggcctgt gccgacccca gcaagatccc ggagcgcgcg gtgcagctca tgcagcaggt ggccagcaac ggcgccaccc tccccagcgc cctgtcggcc tccaagtcca acctggtcat ttccgacccc attccggggg ccaagcccct gccggtgccc cccgagctgg caccgttcgt ggggcggatg tctgcccagg agagcacacc catcatgaac ggcgtcacag gcccggatgg cgaggactac agcccgtggg ctgaccgcaa ggctgcccag cccaaatccc tgtctcctcc gcagtctcag agcaagctca gcgactccta ctccaacaca ctccccgtgc gcaagagcgt gaccccaaaa aacagctatg ccaccaccga gaacaagact ctgcctcgct cgagctccat ggcagccggc ctggagcgca atggccgtat gcgggtgaag gccatcttct cccacgctgc tggggacaac agcaccctcc tgagcttcaa ggagggtgac ctcattaccc tgctggtgcc tgaggcccgc gatggctggc actacggaga gagtgagaag accaagatgc ggggctggtt tcccttctcc tacacccggg tcttggacag cgatggcagt gacaggctgc acatgagcct gcagcaaggg aagagcagca gcacgggcaa cctcctggac aaggacgacc tggccatccc accccccgat tacggcgccg cctcccgggc cttccccgcc cagacggcca gcggcttcaa gcagaggccc tacagtgtgg ccgtgcccgc cttctcccag ggcctggatg actatggagc gcggtccatg agcaggtaa
OMIM
605475
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of BAIAP2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BAIAP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,430 Da
NCBI Official Full Name
Homo sapiens BAI1-associated protein 2, mRNA
NCBI Official Synonym Full Names
BAI1 associated protein 2
NCBI Official Symbol
BAIAP2  [Similar Products]
NCBI Official Synonym Symbols
BAP2; FLAF3; IRSP53
  [Similar Products]
NCBI Protein Information
brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt Protein Name
Brain-specific angiogenesis inhibitor 1-associated protein 2
UniProt Synonym Protein Names
Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53
UniProt Gene Name
BAIAP2  [Similar Products]
UniProt Synonym Gene Names
BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; FLAF3; IRS-58; IRSp53/58; IRSp53; Insulin receptor substrate p53  [Similar Products]
UniProt Entry Name
BAIP2_HUMAN
NCBI Summary for BAIAP2
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
UniProt Comments for BAIAP2
IRSp53: Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir. Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; plasma membrane

Molecular Function: identical protein binding; protein binding; protein C-terminus binding

Biological Process: actin crosslink formation; actin filament bundle formation; axonogenesis; insulin receptor signaling pathway; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; response to bacterium; vascular endothelial growth factor receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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