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anti-BATF antibody :: anti-Human, Mouse BATF Antibody

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Catalog # MBS855740
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

BATF, Antibody

Popular Item
Also Known As

BATF Antibody

Product Synonym Names
B-ATF; SF-HT-activated gene 2 protein; SFA-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
125
OMIM
612476
3D Structure
ModBase 3D Structure for Q16520
Species Reactivity
Human, Mouse
Specificity
BATF antibody detects endogenous levels of total BATF protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human BATF.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-BATF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BATF antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-BATF antibody
IHC: 1:50-1:100
ELISA: 1:1000

Immunohistochemistry (IHC) of anti-BATF antibody
Peptide-+ Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BATF antibody.
anti-BATF antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for BATF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
14,120 Da
NCBI Official Full Name
basic leucine zipper transcriptional factor ATF-like
NCBI Official Synonym Full Names
basic leucine zipper ATF-like transcription factor
NCBI Official Symbol
NCBI Official Synonym Symbols
SFA2; B-ATF; BATF1; SFA-2
  [Similar Products]
NCBI Protein Information
basic leucine zipper transcriptional factor ATF-like
UniProt Protein Name
Basic leucine zipper transcriptional factor ATF-like
UniProt Synonym Protein Names
B-cell-activating transcription factor; B-ATF; SF-HT-activated gene 2 protein; SFA-2
UniProt Gene Name
UniProt Synonym Gene Names
B-ATF; SFA-2  [Similar Products]
NCBI Summary for BATF
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]
UniProt Comments for BATF
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs ().
Product References and Citations for anti-BATF antibody
Dorsey M.J., Oncogene 11:2255-2265(1995). Hasegawa H., Biochem. Biophys. Res. Commun. 222:164-170(1996). Meyer N.P., Mamm. Genome 9:849-852(1998).

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