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anti-Bax antibody :: anti-Human, Mouse Bax Antibody

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Catalog # MBS853493
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

Bax, Antibody

Also Known As

Bax (Ab-167) Antibody

Product Synonym Names
Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
221
OMIM
600040
3D Structure
ModBase 3D Structure for Q07812
Species Reactivity
Human, Mouse
Specificity
Bax (Ab-167) antibody detects endogenous levels of total Bax protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human Bax around the phosphorylation site of threonine 167 (F-G-TP-P-T).
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-Bax antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Bax antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-Bax antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000

Testing Data of anti-Bax antibody
anti-Bax antibody Testing Data image
Western Blot (WB) of anti-Bax antibody
Peptide-+ Western blot analysis of extracts from HepG2 cells, using Bax (Ab-167) antibody. Immunofluorescence analysis of LOVO cells, using Bax (Ab-167) antibody.
anti-Bax antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Bax. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,718 Da
NCBI Official Full Name
apoptosis regulator BAX isoform 1
NCBI Official Synonym Full Names
BCL2 associated X, apoptosis regulator
NCBI Official Symbol
NCBI Official Synonym Symbols
BCL2L4
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NCBI Protein Information
apoptosis regulator BAX
UniProt Protein Name
Apoptosis regulator BAX
UniProt Synonym Protein Names
Bcl-2-like protein 4; Bcl2-L-4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
BCL2L4; Bcl2-L-4  [Similar Products]
NCBI Summary for Bax
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for Bax
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Product References and Citations for anti-Bax antibody
Oltvai Z.N., Cell 74:609-619(1993). Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001). Guo B., Nature 423:456-461(2003).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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