NP_001120712
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
bcl-2-binding component 3 isoform 1
NCBI Official Synonym Full Names
BCL2 binding component 3
NCBI Protein Information
bcl-2-binding component 3
UniProt Protein Name
Bcl-2-binding component 3
UniProt Synonym Protein Names
JFY-1; p53 up-regulated modulator of apoptosis
UniProt Synonym Gene Names
UniProt Entry Name
BBC3_HUMAN
NCBI Summary for BBC3
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
UniProt Comments for BBC3
BBC3B: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. {ECO:0000269|PubMed:11463392}. Isoform 3 does not interact with BCL2. 4 isoforms of the human protein are produced by alternative splicing
Protein type: Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol
Molecular Function: protein binding
Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; apoptosis; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; reduction of endoplasmic reticulum calcium ion concentration; determination of adult life span; response to DNA damage stimulus; negative regulation of growth
Research Articles on BBC3
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Products associated with BBC3 blocking peptide
Pathways associated with BBC3 blocking peptide
Diseases associated with BBC3 blocking peptide
Organs/Tissues associated with BBC3 blocking peptide
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