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anti-BCL-10 antibody :: Mouse anti-Human, Mouse BCL-10 Antibody

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Catalog # MBS850837
Unit / Price
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  0.1 mg  /  $290 +1 FREE 8GB USB
Product Name

BCL-10, Antibody

Popular Item
Full Product Name

BCL-10 Antibody

Product Synonym Names
CLAP; Me10; CIPER; c-E10; CARMEN
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
137245
3D Structure
ModBase 3D Structure for O95999
Isotype
IgG1
Clone Number
4F8
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Purified antibody in PBS containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of human BCL-10 expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Other Notes
Small volumes of anti-BCL-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BCL-10 antibody
Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Applications Tested/Suitable for anti-BCL-10 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)
Application Notes for anti-BCL-10 antibody
WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
FCM: 1:200-1:400
ELISA: 1:10000

Western Blot (WB) of anti-BCL-10 antibody
Figure 1. Western blot analysis using BCL10 mouse mAb against NIH/3T3 (1), Hela (2), MCF-7 (3) and Jurka (4) cell lysate
anti-BCL-10 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-BCL-10 antibody
Figure 2. Immunohistochemical analysis ofparaffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10mouse mAb with DAB staining.
anti-BCL-10 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-BCL-10 antibody
Figure 3.Confocal immunofluorescence analysis of Hela (left) and NTERA-2 (right) cells using NPM mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.
anti-BCL-10 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for BCL-10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26kDa
NCBI Official Full Name
B-cell lymphoma/leukemia 10 isoform 1
NCBI Official Synonym Full Names
B cell CLL/lymphoma 10
NCBI Official Symbol
BCL10  [Similar Products]
NCBI Official Synonym Symbols
CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
  [Similar Products]
NCBI Protein Information
B-cell lymphoma/leukemia 10
UniProt Protein Name
B-cell lymphoma/leukemia 10
UniProt Synonym Protein Names
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10
UniProt Gene Name
BCL10  [Similar Products]
UniProt Synonym Gene Names
CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10  [Similar Products]
NCBI Summary for BCL-10
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Comments for BCL-10
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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