NP_000624.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,337 Da
NCBI Official Full Name
apoptosis regulator Bcl-2 alpha isoform
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 2
NCBI Protein Information
apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50
UniProt Protein Name
Apoptosis regulator Bcl-2
UniProt Entry Name
BCL2_HUMAN
NCBI Summary for Bcl-2 -BH3
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
UniProt Comments for Bcl-2 -BH3
Bcl-2: a antiapoptotic member of the Bcl-2 family. Regulates cell death by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Phosphorylation by JNKs may increase its antiapoptotic functions.
Protein type: Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein
Chromosomal Location of Human Ortholog: 18q21.3
Cellular Component: pore complex; mitochondrial outer membrane; endoplasmic reticulum membrane; nuclear membrane; membrane; mitochondrion; endoplasmic reticulum; cytoplasm; cytosol; nucleus; myelin sheath
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protease binding; protein phosphatase 2A binding; sequence-specific DNA binding; channel activity; protein heterodimerization activity; ubiquitin protein ligase binding; BH3 domain binding; channel inhibitor activity; transcription factor binding
Biological Process: response to nicotine; positive regulation of catalytic activity; focal adhesion formation; developmental growth; renal system process; pigment granule organization and biogenesis; protein polyubiquitination; response to toxin; response to glucocorticoid stimulus; T cell differentiation in the thymus; ear development; lymphoid progenitor cell differentiation; female pregnancy; positive regulation of multicellular organism growth; glomerulus development; negative regulation of mitochondrial depolarization; post-embryonic development; cochlear nucleus development; cellular response to glucose starvation; negative regulation of myeloid cell apoptosis; B cell receptor signaling pathway; regulation of mitochondrial membrane potential; positive regulation of B cell proliferation; negative regulation of ossification; regulation of transmembrane transporter activity; T cell homeostasis; negative regulation of neuron apoptosis; cell growth; defense response to virus; response to drug; spleen development; positive regulation of neuron maturation; release of cytochrome c from mitochondria; axon regeneration; regulation of protein homodimerization activity; actin filament organization; cell aging; digestive tract morphogenesis; regulation of calcium ion transport; positive regulation of cell growth; organ growth; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of osteoblast proliferation; gland morphogenesis; regulation of mitochondrial membrane permeability; regulation of nitrogen utilization; metanephros development; oocyte development; negative regulation of apoptosis; B cell proliferation; negative regulation of autophagy; regulation of protein heterodimerization activity; behavioral fear response; melanin metabolic process; negative regulation of retinal cell programmed cell death; apoptosis; regulation of cell-matrix adhesion; regulation of protein stability; positive regulation of smooth muscle cell migration; protein amino acid dephosphorylation; response to radiation; positive regulation of skeletal muscle fiber development; B cell homeostasis; ovarian follicle development; positive regulation of melanocyte differentiation; melanocyte differentiation; response to gamma radiation; negative regulation of cellular pH reduction; response to iron ion; transmembrane transport; regulation of viral genome replication; negative regulation of cell migration; mesenchymal cell development; ossification; hair follicle morphogenesis; CD8-positive, alpha-beta T cell lineage commitment; thymus development; B cell lineage commitment; male gonad development; peptidyl-threonine phosphorylation; positive regulation of peptidyl-serine phosphorylation; humoral immune response; response to UV-B; endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; peptidyl-serine phosphorylation; response to hydrogen peroxide; axonogenesis; homeostasis of number of cells within a tissue; ureteric bud branching; response to cytokine stimulus; innate immune response; negative regulation of cell growth; response to DNA damage stimulus; induction of apoptosis by oxidative stress
Research Articles on Bcl-2 -BH3
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Products associated with Bcl-2 -BH3 recombinant protein
Pathways associated with Bcl-2 -BH3 recombinant protein
Diseases associated with Bcl-2 -BH3 recombinant protein
Disease Name |
Pubmed Publications |
Lymphoma, Non-Hodgkin Antibodies |
>759 publications with Bcl-2 -BH3 and Lymphoma, Non-Hodgkin |
Carcinoma Antibodies |
>678 publications with Bcl-2 -BH3 and Carcinoma |
Lymphoma, Follicular Antibodies |
>393 publications with Bcl-2 -BH3 and Lymphoma, Follicular |
Necrosis Antibodies |
>380 publications with Bcl-2 -BH3 and Necrosis |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>378 publications with Bcl-2 -BH3 and Lymphoma, Large B-Cell, Diffuse |
Breast Neoplasms Antibodies |
>315 publications with Bcl-2 -BH3 and Breast Neoplasms |
Adenocarcinoma Antibodies |
>273 publications with Bcl-2 -BH3 and Adenocarcinoma |
Disease Progression Antibodies |
>256 publications with Bcl-2 -BH3 and Disease Progression |
Inflammation Antibodies |
>201 publications with Bcl-2 -BH3 and Inflammation |
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies |
>152 publications with Bcl-2 -BH3 and Leukemia, Lymphocytic, Chronic, B-Cell |
Organs/Tissues associated with Bcl-2 -BH3 recombinant protein
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