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anti-BCL10 antibody :: Rabbit Bcl10 (NT) Antibody

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Catalog # MBS194035
Unit / Price
  0.1 mg  /  $400 +1 FREE 8GB USB
anti-BCL10 antibody
Product Name

Bcl10 (NT), Antibody

Also Known As

Anti-Bcl10 (NT) Antibody

Product Synonym Names
Anti-Bcl10 (NT); Bcl10 (NT)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (85731459..85742587, complement). Location: 1p22
OMIM
603517
3D Structure
ModBase 3D Structure for O95999
Host
Rabbit
Specificity
Anti-Bcl10 (NT) [Rabbit antibody to peptide corresponding to aa 5-19 of human Bcl10.]
This antibody recognizes human Bcl10 (31kD).
Form/Format
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Antigen
Peptide corresponding to aa 5-19 of human Bcl10.
Stabilizer
None
Preservatives
0.02% sodium azide.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-BCL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BCL10 antibody
Apoptosis is regulated by death domain (DD)- and/or caspase recruitment domain (CARD)-containing molecules and a caspase family of proteases. CARD-containing cell death regulators include ARC, RAIDD, Apaf-1, caspase- 9, and caspase-2. A novel CARD containing protein was recently identified and designated Bcl10, CIPER, mE10, CARMEN, and CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF- kappa B activation. Bcl10 interacts with caspase-9, enhances procaspase- 9 processing, and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphoma and in B and T cell lymphomas indicating that it may be commonly involved in the pathogenesis of human tumors. Bcl10 is expressed in many human and murine tissues and cell lines.
Product Categories/Family for anti-BCL10 antibody
Applications Tested/Suitable for anti-BCL10 antibody
Immunoblot
Application Notes for anti-BCL10 antibody
Immunoblotting: use at 1:500 dilution.
Positive control: Whole cell lysate of Raji cells.
NCBI/Uniprot data below describe general gene information for BCL10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
26,252 Da[Similar Products]
NCBI Official Full Name
B-cell lymphoma/leukemia 10
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 10
NCBI Official Symbol
BCL10  [Similar Products]
NCBI Official Synonym Symbols
CLAP; mE10; CIPER; c-E10; CARMEN
  [Similar Products]
NCBI Protein Information
B-cell lymphoma/leukemia 10; hCLAP; bcl-10; cCARMEN; cellular-E10; OTTHUMP00000011647; OTTHUMP00000036080; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
UniProt Protein Name
B-cell lymphoma/leukemia 10
UniProt Synonym Protein Names
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10
Protein Family
UniProt Gene Name
BCL10  [Similar Products]
UniProt Synonym Gene Names
CIPER; CLAP  [Similar Products]
UniProt Entry Name
BCL10_HUMAN
NCBI Summary for BCL10
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq]
UniProt Comments for BCL10
Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Transcription, coactivator/corepressor; Tumor suppressor; Apoptosis

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; protein complex; lysosome; immunological synapse; cytosol; lipid raft; T cell receptor complex; cytoplasmic microtubule; perinuclear region of cytoplasm; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; nucleus

Molecular Function: protein C-terminus binding; protein kinase B binding; ubiquitin binding; protein self-association; protease binding; transcription coactivator activity; protein kinase binding; transcription factor binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding

Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; B cell apoptosis; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; lymphotoxin A biosynthetic process; regulation of T cell receptor signaling pathway; neural tube closure; toll-like receptor signaling pathway; innate immune response; cellular defense response; positive regulation of mast cell cytokine production; immunoglobulin mediated immune response; positive regulation of T cell activation; positive regulation of phosphorylation

Disease: Follicular Lymphoma, Susceptibility To, 1; Mesothelioma, Malignant; Testicular Germ Cell Tumor; Gastric Lymphoma, Primary; Immunodeficiency 37
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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