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BCL10 blocking peptide :: BCL-10 Blocking Peptide

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Catalog # MBS152141
Unit / Price
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  0.05 mg  /  $140 +1 FREE 8GB USB
Western Blot (WB)
Product Name

BCL-10 (BCL10), Blocking Peptide

Full Product Name

BCL-10 Peptide

Product Synonym Names
CLAP; mE10; CIPER; c-E10; CARMEN; CLAP; CARD-containing molecule enhancing NF-kappa-B; Bcl-10; B-cell CLL/lymphoma 10
Antibody/Peptide Pairs
BCL-10 peptide (MBS152141) is used for blocking the activity of Bcl-10 antibody (MBS150410)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 603517
3D Structure
ModBase 3D Structure for O95999
Form/Format
Liquid
Concentration
200 ug/mL (lot specific)
Species
Human
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
15 amino amino terminus of human BCL-10.
Preparation and Storage
Store BCL-10 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of BCL10 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for BCL10 blocking peptide
Blocking (BL)
Application Notes for BCL10 blocking peptide
BCL-10 peptide is used for blocking the activity of BCL-10 antibody.

Western Blot (WB) of BCL10 blocking peptide
Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.
BCL10 blocking peptide Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BCL10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,252 Da
NCBI Official Full Name
Homo sapiens CARD-like apoptotic protein (CLAP) mRNA, complete cds
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 10
NCBI Official Symbol
BCL10  [Similar Products]
NCBI Official Synonym Symbols
CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
  [Similar Products]
NCBI Protein Information
B-cell lymphoma/leukemia 10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
UniProt Protein Name
B-cell lymphoma/leukemia 10
UniProt Synonym Protein Names
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10
Protein Family
UniProt Gene Name
BCL10  [Similar Products]
UniProt Synonym Gene Names
CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10  [Similar Products]
UniProt Entry Name
BCL10_HUMAN
NCBI Summary for BCL10
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
UniProt Comments for BCL10
Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Tumor suppressor; Transcription, coactivator/corepressor; Apoptosis

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; protein complex; lysosome; immunological synapse; cytosol; lipid raft; T cell receptor complex; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; nucleus

Molecular Function: protein C-terminus binding; protein kinase B binding; ubiquitin binding; protein self-association; protease binding; transcription coactivator activity; transcription factor binding; protein kinase binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; kinase activator activity; kinase binding

Biological Process: cell death; response to fungus; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; B cell apoptosis; T cell receptor signaling pathway; interleukin-6 biosynthetic process; activation of NF-kappaB transcription factor; negative regulation of mature B cell apoptosis; response to molecule of bacterial origin; protein homooligomerization; response to food; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; protein oligomerization; positive regulation of protein ubiquitination; regulation of T cell receptor signaling pathway; lymphotoxin A biosynthetic process; neural tube closure; toll-like receptor signaling pathway; cellular defense response; innate immune response; immunoglobulin mediated immune response; positive regulation of T cell activation; positive regulation of mast cell cytokine production; positive regulation of phosphorylation

Disease: Follicular Lymphoma, Susceptibility To, 1; Mesothelioma, Malignant; Gastric Lymphoma, Primary; Testicular Germ Cell Tumor; Immunodeficiency 37
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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