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BD1 recombinant protein

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Catalog # MBS539379
Unit / Price
  0.02 mg  /  $310 +1 FREE 8GB USB
BD1 recombinant protein
Product Name

BD1, Recombinant Protein

Also Known As

BD1 protein

Product Synonym Names
BD 1; BD-1 protein; BD 1 protein; BD1; BD-1; beta-Defensin 1 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
68
Sequence
Region of BD1 protein correspond ing to amino acids DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK.
OMIM
602056
3D Structure
ModBase 3D Structure for P60022
Host
Human
Purity/Purification
> 98% pure
Form/Format
Supplied as a lyophilized powder.
Protein Type
Recombinant
Biological Significance
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
Bioactivity
Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of BD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BD1 recombinant protein
Purified recombinant Human BD1 protein
Product Categories/Family for BD1 recombinant protein
Applications Tested/Suitable for BD1 recombinant protein
User optimized
NCBI/Uniprot data below describe general gene information for BD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
3.9 kDa
NCBI Official Full Name
beta-defensin 1 preproprotein
NCBI Official Synonym Full Names
defensin, beta 1
NCBI Official Symbol
DEFB1  [Similar Products]
NCBI Official Synonym Symbols
BD1; HBD1; DEFB-1; DEFB101
  [Similar Products]
NCBI Protein Information
beta-defensin 1
UniProt Protein Name
Beta-defensin 1
UniProt Synonym Protein Names
Defensin, beta 1
UniProt Gene Name
DEFB1  [Similar Products]
UniProt Synonym Gene Names
BD1; HBD1; BD-1; hBD-1  [Similar Products]
UniProt Entry Name
DEFB1_HUMAN
NCBI Summary for BD1
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
UniProt Comments for BD1
defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to Gram-positive bacterium; response to bacterium; innate immune response in mucosa; antibacterial humoral response; innate immune response; immune response; response to testosterone stimulus; chemotaxis; acute inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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