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bIGF1 recombinant protein :: Insulin Like Growth Factor-1 Recombinant Protein

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Catalog # MBS142303
Unit / Price
  0.01 mg  /  $140 +1 FREE 8GB USB
  0.05 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $1,900 +2 FREE 8GB USB
bIGF1 recombinant protein
Product Name

Insulin Like Growth Factor-1 (bIGF1), Recombinant Protein

Popular Item
Also Known As

Recombinant Rabbit Insulin Like Growth Factor-1

Product Synonym Names
IGF1 Rabbit; Insulin-Like Growth Factor 1 Rabbit Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Mechano growth factor; MGF
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
143
Sequence
MTAGPETLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKP
3D Structure
ModBase 3D Structure for Q95222
Host
E Coli
Purity/Purification
Greater than 98.0% as determined by: (a) Gel-filtration chromatography under non denaturing conditions. (b) Analysis by SDS-PAGE.
Form/Format
The protein was lyophilized from a concentrated (0.5 mg/ml) solution with 0.02% NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility
It is recommended to reconstitute the lyophilized rbIGF-I in sterile 0.4% NaHCO3 adjusted, not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
IGF-I is biologically active when compared to human IGF-1. The ED50, calculated by the dose -dependent proliferation of human MCF/7 cells is 5 to 25ng/ml in the cell culture mixture dependent on culture conditions. Its activity consists of 30-40 % compared to human IGF-1.
Preparation and Storage
Lyophilized Insulin-Like Growth Factor-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IGF1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Other Notes
Small volumes of bIGF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
bIGF1 recombinant protein
Description: Insulin-Like Growth Factor-I Rabbit Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 7639 Dalton.

Introduction: The IGFs comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone. Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin'. Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A, and somatomedin B. IGF-1 is a small protein secreted mostly but not exclusively by the liver and circulating in blood mostly as a complex with several IGF binding proteins. It has growth-regulating, insulin-like, and mitogenic functions and it is secreted in response to growth hormone stimulation.
NCBI/Uniprot data below describe general gene information for bIGF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,205 Da
NCBI Official Full Name
insulin-like growth factor I
NCBI Official Symbol
NCBI Official Synonym Symbols
IGF-IB
  [Similar Products]
NCBI Protein Information
insulin-like growth factor I; IGF-I; insulin-like growth factor IB; somatomedin
UniProt Protein Name
Insulin-like growth factor I
UniProt Synonym Protein Names
Somatomedin
UniProt Gene Name
UniProt Synonym Gene Names
IGF-1; IGF-I  [Similar Products]
UniProt Entry Name
IGF1_RABIT
UniProt Comments for bIGF1
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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