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a-Methyl-L-tryptophan Biochemical

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Catalog # MBS6053559
Unit / Price
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  10 mg  /  $470 +1 FREE 8GB USB
a-Methyl-L-tryptophan biochemical
Product Name

a-Methyl-L-tryptophan, Biochemical

Popular Item
Full Product Name

a-Methyl-L-tryptophan ((S)-a-Methyltryptophan)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Host
Synthetic
Purity/Purification
~90%
Form/Format
Supplied as an off-white solid.
CAS Number
16709-25-4
Molecular Formula
C12H14N2O2
Atmosphere
Inert gas
Melting Point
As reported
Method for Determining Identity
Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric analysis
Solubility
As reported
TLC Conditions
As reported

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert gas.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Preparation and Storage
-20 degree C
Other Notes
Small volumes of a-Methyl-L-tryptophan biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for a-Methyl-L-tryptophanpurchase
Contents for alpha Methyl L-tryptophan ((S)-a-Methyltryptophan):

(S)-alpha Methyl tryptophan ( a-Methyl-L-tryptophan or methyl dl tryptophan ) is a competitive inhibitor of indoleamine 2,3-dioxygenase.
The enzyme indoleamine-pyrrole 2,3-dioxygenase is encoded by the IDO1 gene. It catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. Additionally,iso indoleamine-pyrrole 2,3-dioxygenase rate-limiting enzyme of tryptophan catabolism through kynurenine/ tryptophan pathway and causes depletion of tryptophan which can cause halted growth of microbes as well as T cells. Literature data has indicated linked to some viral mechanisms e.g. influenza virus and potentially cancer. Tryptophan oxidation via the kynurenine pathway is an important mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin pathway has also been linked to malignant progression in breast cancer.
Inhibition of the expression indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with anti tumor responses
When used as a research tool in rodents, literature has shown that a-methyltryptophan given to experimental animals gives rise to brain alpha-methylserotonin, which substitutes for serotonin in certain behavioral and functional tests.
This protein product has a wide variation of research applications.
Molecular Weight
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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