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anti-BIRC5 antibody :: Rabbit Survivin (CT) Antibody

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Catalog # MBS194143
Unit / Price
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  0.1 mg  /  $415 +1 FREE 8GB USB
anti-BIRC5 antibody
Product Name

Survivin (CT) (BIRC5), Antibody

Full Product Name

Anti-Survivin (CT) Antibody

Product Synonym Names
Anti-Survivin (CT); Survivin (CT)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8I009
Host
Rabbit
Specificity
Anti-Survivin (CT) [Rabbit antibody to peptide corresponding to aa 129 to aa 129-142 of human survivin.]
This antibody recognizes human survivin (17 kD).
Form/Format
100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chromatography.
Antigen
Peptide corresponding to aa 129-142 of human survivin.
Stabilizer
None
Preservatives
0.02% sodium azide.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-BIRC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BIRC5 antibody
Apoptosis is related to many diseases and is triggered by a variety of stimuli including members of the TNF family. Apoptosis can be prevented by the inhibitor of apoptosis proteins (IAPs). IAPs constitute a conserved gene family that binds to and inhibits cell death proteases. A novel IAP has been identified and designated survivin. Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is expressed predominantly in tissues of embryos, transformed cell lines, and many human cancers.
Product Categories/Family for anti-BIRC5 antibody
Applications Tested/Suitable for anti-BIRC5 antibody
Immunoblot
Application Notes for anti-BIRC5 antibody
Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: MOLT4 cell lysate.
NCBI/Uniprot data below describe general gene information for BIRC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,271 Da[Similar Products]
NCBI Official Full Name
baculoviral IAP repeat-containing protein 5
NCBI Official Symbol
BIRC5  [Similar Products]
NCBI Official Synonym Symbols
BIRC5
  [Similar Products]
NCBI Protein Information
baculoviral IAP repeat-containing protein 5; survivin; apoptosis inhibitor survivin
UniProt Protein Name
Baculoviral IAP repeat-containing protein 5
UniProt Synonym Protein Names
Apoptosis inhibitor survivin
UniProt Gene Name
BIRC5  [Similar Products]
UniProt Entry Name
BIRC5_CANFA
UniProt Comments for BIRC5
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7

Subunit structure: Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state

By similarity. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Chromosome › centromere

By similarity. Cytoplasm › cytoskeleton › spindle

By similarity. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes

By similarity. UniProtKB O15392

Domain: The BIR repeat is necessary and sufficient for HBXIP binding

Post-translational modification: Ubiquitination is required for centrosomal targeting

By similarity.In vitro phosphorylation at Thr-117 by AURKB/STK12 prevents interaction with INCENP and localization to mitotic chromosomes

Sequence similarities: Belongs to the IAP family.Contains 1 BIR repeat.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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