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anti-BIRC5 antibody :: Survivin Antibody

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Catalog # MBS8511201
Unit / Price
  0.1 mg  /  $290 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Survivin (BIRC5), Antibody

Popular Item
Also Known As

Phospho-Survivin (Thr117) Antibody

Product Synonym Names
API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC5; Baculoviral IAP repeat-containing protein 5; IAP4; TIAP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
137
OMIM
603352
3D Structure
ModBase 3D Structure for O15392
Species Reactivity
Human, Mouse, Rat
Specificity
Phospho-Survivin (Thr117) Antibody detects endogenous levels of Survivin only when phosphorylated at Threonine 117
Purity/Purification
Immunogen affinity purified
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4 150mM NaCI, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Survivin around the phosphorylation site of Threonine 117
Preparation and Storage
Store at -20°C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-BIRC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BIRC5 antibody
Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia.
Applications Tested/Suitable for anti-BIRC5 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-BIRC5 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-BIRC5 antibody
Western blot analysis of Survivin phosphorylation expression in A549 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
anti-BIRC5 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BIRC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
baculoviral IAP repeat-containing protein 5 isoform 2
NCBI Official Synonym Full Names
baculoviral IAP repeat containing 5
NCBI Official Symbol
BIRC5  [Similar Products]
NCBI Official Synonym Symbols
API4; EPR-1
  [Similar Products]
NCBI Protein Information
baculoviral IAP repeat-containing protein 5
UniProt Protein Name
Baculoviral IAP repeat-containing protein 5
UniProt Synonym Protein Names
Apoptosis inhibitor 4; Apoptosis inhibitor survivin
UniProt Gene Name
BIRC5  [Similar Products]
UniProt Synonym Gene Names
API4; IAP4  [Similar Products]
NCBI Summary for BIRC5
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
UniProt Comments for BIRC5
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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