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Birc5 recombinant protein :: Baculoviral IAP repeat-containing protein 5 Recombinant Protein

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Catalog # MBS1238412
Unit / Price
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $850 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,070 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,090 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,555 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,665 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,080 +2 FREE 8GB USB
SDS-PAGE
Product Name

Baculoviral IAP repeat-containing protein 5 (Birc5), Recombinant Protein

Popular Item
Also Known As

Recombinant Mouse Baculoviral IAP repeat-containing protein 5

Product Synonym Names
Apoptosis inhibitor 4; Apoptosis inhibitor survivin; TIAP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-140aa; Full Length
Sequence Length
121
Sequence
MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE FLKLDRQRAK NKIAKETNNK QKEFEETAKT TRQSIEQLAA
3D Structure
ModBase 3D Structure for O70201
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Birc5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forBirc5purchase
BIRC5 is regulatory molecule from inhibitor of apoptosis protein family that controls cell proliferation and apoptosis prevention; its expression peaks during mitosis and it acts as localization regulator for chromosome passage protein complex and is essential for alignment and segregation of chromosomes during this phase. Alternative names for BIRC5 in NCBI and UniProt data bases are baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, apoptosis inhibitor survivin and survivin variant 3 alpha. Recombinant BIRC5 is murine protein available as product of following expression systems: E.coli, yeast, baculovirus or mammalian cells. BIRC5 is expressed as His-tagged polypeptide chain with length of 140 amino acids corresponding to sequence 1-140aa of native protein; exact amino acid sequence is presented in datasheet. Recombinant BIRC5 is purified and supplied at purity greater than 90% (by SDS-PAGE). Protein is provided in liquid form in Tris-based buffer with 50% glycerol. Recombinant BIRC5 must be stored frozen at -20°C or -80°C; repetitive freeze/thaw cycles are not recommended.
Related Product Information for
Birc5 recombinant protein
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movent to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.

Birc5 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Birc5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32.3kD
NCBI Official Full Name
baculoviral IAP repeat-containing protein 5 isoform 3
NCBI Official Synonym Full Names
baculoviral IAP repeat-containing 5
NCBI Official Symbol
Birc5  [Similar Products]
NCBI Official Synonym Symbols
Api4; TIAP; AAC-11; survivin40
  [Similar Products]
NCBI Protein Information
baculoviral IAP repeat-containing protein 5
UniProt Protein Name
Baculoviral IAP repeat-containing protein 5
UniProt Synonym Protein Names
Apoptosis inhibitor 4; Apoptosis inhibitor survivin; TIAP
UniProt Gene Name
Birc5  [Similar Products]
UniProt Synonym Gene Names
Api4; Iap4  [Similar Products]
UniProt Entry Name
BIRC5_MOUSE
NCBI Summary for Birc5
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
UniProt Comments for Birc5
Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.

Protein type: Apoptosis

Cellular Component: apical plasma membrane; centriole; chromosome; chromosome, pericentric region; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; interphase microtubule organizing center; kinetochore; microtubule; midbody; nuclear chromosome; nucleus; spindle microtubule

Molecular Function: caspase inhibitor activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; enzyme binding; identical protein binding; metal ion binding; microtubule binding; protease inhibitor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; Ran GTPase binding; tubulin binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: apoptosis; cell cycle; cell division; chromosome segregation; cytokinesis; embryonic development; establishment of chromosome localization; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; mitosis; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of neuron apoptosis; negative regulation of peptidase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; protein complex localization; regulation of mitotic cell cycle; regulation of signal transduction; regulation of transcription, DNA-dependent; spindle checkpoint; transcription, DNA-dependent
Product References and Citations for Birc5 recombinant protein
Mammalian inhibitor of apoptosis (IAP) homolog.Uren A.G., Vaux D.L.Kobayashi K., Otaki M., Ogasawara T., Tokuhisa T. Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.Conway E.M., Pollefeyt S., Cornelissen J., DeBaere I., Steiner-Mosonyi M., Ong K., Baens M., Collen D., Schuh A.C.Blood 95:1435-1442(2000) Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.Muchmore S.W., Chen J., Jakob C., Zakula D., Matayoshi E.D., Wu W., Zhang H., Li F., Ng S.C., Altieri D.C.Mol. Cell 6:173-182(2000)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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