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BLVRA recombinant protein :: Biliverdin Reductase A Recombinant Protein

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Catalog # MBS143538
Unit / Price
  0.01 mg  /  $140 +1 FREE 8GB USB
  0.05 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $1,800 +2 FREE 8GB USB
BLVRA recombinant protein
Product Name

Biliverdin Reductase A (BLVRA), Recombinant Protein

Also Known As

Recombinant Human Biliverdin Reductase A

Product Synonym Names
BLVRA Human; Biliverdin Reductase A Human Recombinant; Biliverdin reductase A; BVR A; Biliverdin-IX alpha-reductase; BLVRA; BLVR; BVR; BVRA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
296
Sequence
MAEPERKFGV VVVGVGRAGS VRMRDLRNPH PSSAFLNLIG FVSRRELGSI DGVQQISLED ALSSQEVEVA YICSESSSHE DYIRQFLNAG KHVLVEYPMT LSLAAAQELW ELAEQKGKVL HEEHVELLME EFAFLKKEVV GKDLLKGSLL FTAGPLEEER FGFPAFSGIS RLTWLVSLFG ELSLVSATLE ERKEDQYMKM TVCLETEKKS PLSWIEEKGP GLKRNRYLSF HFKSGSLENV PNVGVNKNIF LKDQNIFVQK LLGQFSEKEL AAEKKRILHC LGLAEEIQKY CCSRK
OMIM
109750
3D Structure
ModBase 3D Structure for P53004
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The BLVRA solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Sterile Filtered colorless solution.
Other Notes
Small volumes of BLVRA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BLVRA recombinant protein
Description: BLVRA Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids (3-296 a.a. and Methionine at N-terminus) and having a molecular mass of 33.3kDa (molecular weight on SDS-PAGE will shift up).The BLVRA is purified by proprietary chromatographic techniques.

Introduction: Biliverdin reductase A (BLVRA) is a member of the gfo/idh/mocA family. BLVRA is an enzyme that converts biliverdin to bilirubin, converting a double-bond between the second and third pyrrole ring into a single-bond. BLVRA reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the simultaneous oxidation of a NADH or NADPH cofactor (Bilirubin + NAD(P)+ = biliverdin + NAD(P)H).BLVRA is a regulator for induction of activating transcription factor-2 and heme oxygenase-1. Furthermore, BLVRA enhances the role of HO-1 in cytoprotection and provides cytoprotection independent of heme degradation. In addition, Bilirubin while acting as a cytoprotective antioxidant is itself oxidized to biliverdin and subsequently recycled by biliverdin reductase back to bilirubin.
NCBI/Uniprot data below describe general gene information for BLVRA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,428 Da
NCBI Official Full Name
biliverdin reductase A
NCBI Official Synonym Full Names
biliverdin reductase A
NCBI Official Symbol
BLVRA  [Similar Products]
NCBI Official Synonym Symbols
BVR; BLVR; BVRA
  [Similar Products]
NCBI Protein Information
biliverdin reductase A; BVR A; biliverdin-IX alpha-reductase
UniProt Protein Name
Biliverdin reductase A
UniProt Synonym Protein Names
Biliverdin-IX alpha-reductase
Protein Family
UniProt Gene Name
BLVRA  [Similar Products]
UniProt Synonym Gene Names
BLVR; BVR; BVR A  [Similar Products]
UniProt Entry Name
BIEA_HUMAN
NCBI Summary for BLVRA
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for BLVRA
BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.

Protein type: Kinase, protein; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor); EC 1.3.1.24; ATYPICAL group; BLVRA family

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol

Molecular Function: zinc ion binding; biliverdin reductase activity

Biological Process: heme catabolic process; porphyrin metabolic process

Disease: Hyperbiliverdinemia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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