NP_005439.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,055 Da
NCBI Official Full Name
bone morphogenetic protein 15
NCBI Official Synonym Full Names
bone morphogenetic protein 15
NCBI Protein Information
bone morphogenetic protein 15; BMP-15; GDF-9B; growth/differentiation factor 9B
UniProt Protein Name
Bone morphogenetic protein 15
UniProt Synonym Protein Names
Growth/differentiation factor 9B; GDF-9B
UniProt Synonym Gene Names
UniProt Entry Name
BMP15_HUMAN
NCBI Summary for BMP-15
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.[provided by RefSeq, Sep 2009]
UniProt Comments for BMP-15
BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp11.2
Cellular Component: extracellular space; cytoplasm
Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; regulation of apoptosis; ovarian follicle development; granulosa cell development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development
Disease: Ovarian Dysgenesis 2
Research Articles on BMP-15
Precautions
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Products associated with BMP-15 elisa kit
Pathways associated with BMP-15 elisa kit
Diseases associated with BMP-15 elisa kit
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