View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List BMP-2 clia kit :: Human BMP-2 CLIA Kit Catalog # MBS9510762 Unit / Price 1 Kit / $485 +1 FREE 8GB USB 5x1 Kit / $2,230 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name BMP-2, CLIA Kit Full Product Name BMP-2 (Human) LumiAb ELISA Kit Product Synonym Names Human BMP-2; Bone morphogenetic protein 2A Product Gene Name BMP-2 clia kit[Similar Products] Product Synonym Gene Name BMP2[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sample Manual Insert Download Sample PDF Manual View Sample PDF Manual OMIM 112261 3D Structure ModBase 3D Structure for P12643 Species Reactivity Human Specificity The LumiAb Human beta-NGF ELISA is capable of recognizing both recombinant and naturally produced Human beta-NGF proteins. The antigens listed below were tested at 50 ng/ml and exhibited 100% cross reactivity. Assay Type Quantitative Sandwich Sensitivity 8 pg/ml. Preparation and Storage Store at 4 degree C for 6 months. Product Note Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details. Other Notes Small volumes of BMP-2 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for BMP-2 clia kit Principle of the Assay: The LumiAb Human beta-NGF Chemiluminescent ELISA Kit contains the components necessary for quantitative determination of natural or recombinant Human beta-NGF concentrations within any experimental sample including cell lysates, serum and plasma. This particular immunoassay utilizes the quantitative technique of a "Sandwich" Enzyme-Linked Immunosorbent Assay (ELISA) where the target protein (antigen) is bound in a "sandwich" format by the primary capture antibodies coated to each well-bottom and the secondary detection antibodies added subsequently by the investigator. The capture antibodies coated to the bottom of each well are specific for a particular epitope on Human beta-NGF while the user-added detection antibodies bind to epitopes on the captured target protein. Amid each step of the procedure, a series of wash steps must be performed to ensure the elimination of non-specific binding between proteins to other proteins or to the solid phase. After incubation and "sandwiching" of the target antigen, a peroxidase enzyme is conjugated to the constant heavy chain of the secondary antibody (either covalently or via Avidin/Streptavidin-Biotin interactions), allowing for a sensitive luminescent reaction to ensue upon substrate addition. When the Peroxide Enhancer solution is added, the reaction catalyzed by peroxidase yields light that is representative of the antigen concentration. After a brief incubation, the microplate can be read with a luminometer, allowing for generation of a standard curve and subsequent determination of protein concentration!!Background/Introduction: Human beta-NGF, also known as Nerve Growth Factor beta, is a 241 amino acid cytokine protein encoded by the NGFB gene at locus 1p13.1 on chromosome 1. After initial synthesis of the premature beta-NGF peptide, it is subject to proteolytic processing and cleavage, thus separating the 18 residue signal sequence, the 103 residue propeptide and the 120 residue mature beta-NGF protein. beta-NGF is a secreted protein with sympathetic as well as embryonic nerve growth stimulating activity which homodimerizes and is incorporated into a larger complex that is involved in the regulation of growth and differentiation of sympathetic and certain sensory neurons. Mutations in this gene have often been associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5) and dysregulation of the NGFB's expression can lead to allergic rhinitis. Product Categories/Family for BMP-2 clia kit Luminometer Sandwich ELISA Typical Testing Data/Standard Curve (for reference only) of BMP-2 clia kit TOP Sample Manual Insert of MBS9510762. NCBI/Uniprot data below describe general gene information for BMP-2. It may not necessarily be applicable to this product. NCBI GI # 115068 NCBI GeneID 650 NCBI Accession # P12643.1 [Other Products] UniProt Primary Accession # P12643 [Other Products] UniProt Related Accession # P12643[Other Products] TOP NCBI Official Full Name Bone morphogenetic protein 2 NCBI Official Synonym Full Names bone morphogenetic protein 2 NCBI Official Symbol BMP2 [Similar Products] NCBI Official Synonym Symbols BDA2; BMP2A; SSFSC [Similar Products] NCBI Protein Information bone morphogenetic protein 2 UniProt Protein Name Bone morphogenetic protein 2 UniProt Synonym Protein Names Bone morphogenetic protein 2A; BMP-2A Protein Family BMP-2-inducible protein kinase UniProt Gene Name BMP2 [Similar Products] UniProt Synonym Gene Names BMP2A; BMP-2; BMP-2A [Similar Products] UniProt Entry Name BMP2_HUMAN TOP NCBI Summary for BMP-2 This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] TOP UniProt Comments for BMP-2 Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). Research Articles on BMP-2 1. The extent of calcification correlated positively with the flow velocity, as did the mRNA and protein levels of TGF-beta1, BMP2, and MSX2. These findings indicate that TGF-beta1/BMP2 signaling is involved in valve calcification induced by abnormal mechanical stimulation. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with BMP-2 clia kit Reference Product PubMed Publications BMPR2 clia kit >206 publications with BMP-2 and BMPR2 BMPR1A clia kit >179 publications with BMP-2 and BMPR1A SMAD4 clia kit >95 publications with BMP-2 and SMAD4 BMPR1B clia kit >58 publications with BMP-2 and BMPR1B SMAD7 clia kit >33 publications with BMP-2 and SMAD7 NOG clia kit >11 publications with BMP-2 and NOG ACVR2B clia kit >9 publications with BMP-2 and ACVR2B GREM2 clia kit >8 publications with BMP-2 and GREM2 CHRD clia kit >3 publications with BMP-2 and CHRD SOSTDC1 clia kit >2 publications with BMP-2 and SOSTDC1 Pathways associated with BMP-2 clia kit Products by Pathway Pathway Diagram Adipogenesis Pathway antibodies Adipogenesis Pathway Diagram BDNF Signaling Pathway antibodies BDNF Signaling Pathway Diagram BMP Signaling Pathway antibodies BMP Signaling Pathway Diagram BMP Signaling Pathway antibodies BMP Signaling Pathway Diagram BMP Signalling And Regulation Pathway antibodies BMP Signalling And Regulation Pathway Diagram Basal Cell Carcinoma Pathway antibodies Basal Cell Carcinoma Pathway Diagram Basal Cell Carcinoma Pathway antibodies Basal Cell Carcinoma Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Cytokine-cytokine Receptor Interaction Pathway antibodies Cytokine-cytokine Receptor Interaction Pathway Diagram Elastic Fibre Formation Pathway antibodies Elastic Fibre Formation Pathway Diagram Diseases associated with BMP-2 clia kit Disease Name Pubmed Publications Bone Diseases Antibodies >567 publications with BMP-2 and Bone Diseases Necrosis Antibodies >112 publications with BMP-2 and Necrosis Inflammation Antibodies >93 publications with BMP-2 and Inflammation Pain Antibodies >46 publications with BMP-2 and Pain Hypertrophy Antibodies >45 publications with BMP-2 and Hypertrophy Hypertension Antibodies >44 publications with BMP-2 and Hypertension Fibrosis Antibodies >34 publications with BMP-2 and Fibrosis Kidney Diseases Antibodies >32 publications with BMP-2 and Kidney Diseases Breast Neoplasms Antibodies >32 publications with BMP-2 and Breast Neoplasms Atherosclerosis Antibodies >25 publications with BMP-2 and Atherosclerosis Organs/Tissues associated with BMP-2 clia kit Organ/Tissue Name Pubmed Publications Bone Antibodies >4170 publications with BMP-2 and Bone Connective Tissue Antibodies >647 publications with BMP-2 and Connective Tissue Embryonic Tissue Antibodies >455 publications with BMP-2 and Embryonic Tissue Heart Antibodies >192 publications with BMP-2 and Heart Brain Antibodies >161 publications with BMP-2 and Brain Kidney Antibodies >94 publications with BMP-2 and Kidney Lung Antibodies >82 publications with BMP-2 and Lung Liver Antibodies >70 publications with BMP-2 and Liver Eye Antibodies >63 publications with BMP-2 and Eye Uterus Antibodies >29 publications with BMP-2 and Uterus TOP © 2006-24 MyBioSource.com. 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