NP_006120.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,655 Da
NCBI Official Full Name
bone morphogenetic protein 1 isoform 3
NCBI Official Synonym Full Names
bone morphogenetic protein 1
NCBI Protein Information
bone morphogenetic protein 1; mammalian tolloid protein; procollagen C-proteinase 3; procollagen C-endopeptidase
UniProt Protein Name
Bone morphogenetic protein 1
UniProt Synonym Protein Names
Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP
UniProt Synonym Gene Names
UniProt Entry Name
BMP1_HUMAN
NCBI Summary for BMP1
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
UniProt Comments for BMP1
BMP1: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Defects in BMP1 are a cause of autosomal recessive osteogenesis imperfecta (AR-OI). A connective tissue disorder characterized by bone fragility, progressively deforming bones, bowing of limbs due to multiple fractures, very short stature, a triangular face, severe scoliosis, and grayish sclera. AR-OI due to BMP1 mutations belongs to the group of osteogenesis imperfecta type III in the Sillence classification. Belongs to the peptidase M12A family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.24.19; Cytokine
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; extracellular region
Molecular Function: peptidase activity; growth factor activity; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; cytokine activity; calcium ion binding
Biological Process: extracellular matrix disassembly; ossification; extracellular matrix organization and biogenesis; multicellular organismal development; lipoprotein metabolic process; cell differentiation; proteolysis; skeletal development; cartilage condensation
Disease: Osteogenesis Imperfecta, Type Xiii
Research Articles on BMP1
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Products associated with BMP1 elisa kit
Pathways associated with BMP1 elisa kit
Diseases associated with BMP1 elisa kit
Organs/Tissues associated with BMP1 elisa kit
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