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BMP4 recombinant protein :: Bone Morphogenetic Protein 4 Recombinant Protein

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Catalog # MBS650854
Unit / Price
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  0.002 mg  /  $345 +1 FREE 8GB USB
  0.01 mg  /  $420 +1 FREE 8GB USB
BMP4 recombinant protein
Product Name

Bone Morphogenetic Protein 4 (BMP4), Recombinant Protein

Popular Item
Full Product Name

Bone Morphogenetic Protein 4, Recombinant, Human (BMP4, DVR4)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR.
Chromosome Location
Chromosome: 14; NC_000014.8 (54416454..54423554, complement). Location: 14q22-q23
OMIM
112262
3D Structure
ModBase 3D Structure for P12644
Host
E Coli
Purity/Purification
Highly Purified
95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.
Form/Format
Supplied as a lyophilized powder from a concentrated sterile solution containing no additives. Reconstitute in sterile 20mM acetic acid to 0.1mg/ml, which can then be further diluted with 0.1% HSA or BSA in other aqueous solutions.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months. Reconstitute with sterile 20mM acetic acid. Aliquot and store at -20 degree C. Stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer with 0.1% HSA or BSA.
Other Notes
Small volumes of BMP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BMP4 recombinant protein
Recombinant Human BMP-4 produced in E.Coli is a monomeric, non-glycosylated, Polypeptide chain containing 116aa and having a molecular mass of ~13kD.
Applications Tested/Suitable for BMP4 recombinant protein
ELISA (EL/EIA), Western Blot (WB)
Application Notes for BMP4 recombinant protein
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for BMP4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
bone morphogenetic protein 4
NCBI Official Synonym Full Names
bone morphogenetic protein 4
NCBI Official Symbol
NCBI Official Synonym Symbols
ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
  [Similar Products]
NCBI Protein Information
bone morphogenetic protein 4; BMP-4; BMP-2B; OTTHUMP00000178992; bone morphogenetic protein 2B
UniProt Protein Name
Bone morphogenetic protein 4
UniProt Synonym Protein Names
Bone morphogenetic protein 2B
UniProt Gene Name
UniProt Synonym Gene Names
BMP2B; DVR4  [Similar Products]
UniProt Entry Name
BMP4_HUMAN
NCBI Summary for BMP4
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq]
UniProt Comments for BMP4
Function: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction

Subunit structure: Homodimer; disulfide-linked

By similarity. Interacts with GREM2

By similarity and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD

By similarity. Ref.5

Subcellular location: Secreted › extracellular space › extracellular matrix.

Tissue specificity: Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.

Involvement in disease: Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [

MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Ref.7Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11) [

MIM:600625]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero. Ref.9

Sequence similarities: Belongs to the TGF-beta family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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