AAD31850.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,297 Da
NCBI Official Full Name
corin
NCBI Official Synonym Full Names
corin, serine peptidase
NCBI Official Synonym Symbols
CRN; ATC2; Lrp4; PEE5; TMPRSS10 [Similar Products]
NCBI Protein Information
atrial natriuretic peptide-converting enzyme; pro-ANP-convertase; pro-ANP-converting enzyme; transmembrane protease serine 10; heart-specific serine proteinase ATC2
UniProt Protein Name
Atrial natriuretic peptide-converting enzyme
UniProt Synonym Protein Names
Corin; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; Transmembrane protease serine 10Cleaved into the following 5 chains:Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment
UniProt Synonym Gene Names
UniProt Entry Name
CORIN_HUMAN
NCBI Summary for Corin
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
UniProt Comments for Corin
CORIN: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.-; Protease; Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: cell surface; integral to plasma membrane; integral to membrane; plasma membrane; extracellular region
Molecular Function: serine-type endopeptidase activity
Biological Process: regulation of blood pressure; peptide hormone processing; female pregnancy; proteolysis; regulation of systemic arterial blood pressure by atrial natriuretic peptide
Disease: Preeclampsia/eclampsia 5
Research Articles on Corin
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Products associated with Corin elisa kit
Pathways associated with Corin elisa kit
Diseases associated with Corin elisa kit
Organs/Tissues associated with Corin elisa kit
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