NP_284941.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
71,401 Da
NCBI Official Full Name
mitofusin-1
NCBI Official Synonym Full Names
mitofusin 1
NCBI Official Synonym Symbols
NCBI Protein Information
mitofusin-1
UniProt Protein Name
Mitofusin-1
UniProt Synonym Protein Names
Fzo homolog; Transmembrane GTPase MFN1
NCBI Summary for MFN1
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
UniProt Comments for MFN1
MFN1: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Belongs to the mitofusin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component: mitochondrial outer membrane; mitochondrion
Molecular Function: protein binding
Biological Process: macroautophagy; mitochondrial fusion
Research Articles on MFN1
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Products associated with MFN1 elisa kit
Pathways associated with MFN1 elisa kit
Diseases associated with MFN1 elisa kit
Organs/Tissues associated with MFN1 elisa kit
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