NP_003341.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
16,363 Da
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 variant 2
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2 variant 2
NCBI Official Synonym Symbols
MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1 [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 variant 2; DDVit 1; MMS2 homolog; vitamin D3-inducible protein; 1 alpha,25-dihydroxyvitamin D3-inducible; enterocyte differentiation promoting factor; enterocyte differentiation-promoting factor 1; enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 variant 2
UniProt Synonym Protein Names
DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein
UniProt Synonym Gene Names
UniProt Entry Name
UB2V2_HUMAN
NCBI Summary for UBE2V2
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for UBE2V2
UBE2V2: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 8q11.21
Cellular Component: cytoplasm; nucleus; UBC13-MMS2 complex
Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding
Biological Process: regulation of DNA repair; cell proliferation; positive regulation of synaptogenesis; protein polyubiquitination; positive regulation of DNA repair; postreplication repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; DNA double-strand break processing; protein ubiquitination; negative regulation of neuron apoptosis
Research Articles on UBE2V2
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Products associated with UBE2V2 elisa kit
Pathways associated with UBE2V2 elisa kit
Diseases associated with UBE2V2 elisa kit
Organs/Tissues associated with UBE2V2 elisa kit
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