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bre recombinant protein :: BRCA1-A complex subunit BRE (bre) Recombinant Protein

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Catalog # MBS1285567
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $800 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $885 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,070 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,115 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,200 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,360 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,360 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,615 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $1,785 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,100 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,160 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,205 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,245 +4 FREE 8GB USB
bre recombinant protein
Product Name

BRCA1-A complex subunit BRE (bre), Recombinant Protein

Full Product Name

Recombinant Danio rerio BRCA1-A complex subunit BRE (bre)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-386aa, full length protein
Sequence
MNSLSPELAL SRISPELRPL LCSIVRNGRV GLDSSSCLRI TDLKSGCTSL MPGPCCDRFK LHIPYAGETL KWDIIFNARD PELPPDFIFG EDADFLPEPS ELPNLVSWDS GKPECLLLLV KEMLQQYHQY QCQRLRDSSR LLFEYDSLLE DPNYGRNMEI YAGRKNSWTG EFSARFLLKL PVDFSNIPIY LLKDTALDPG EDVALLSVSF EDAEATQVFP KLYLSPSIEH ALGGSSALHI PAFPSGGCLI DYVPQVCQLL TNKVQYVIQG YHKRREYIAA FLSHFGMGVV EYDAVGFTKL TLLLMWKDFC FLVHVDLPLY FPRDQPTLTF QSIYHFTSSG QLYSQVQKSY PYSPRWDGNE MAKRAKAYFK SFIPQFQEGA FANGKL
3D Structure
ModBase 3D Structure for Q568D5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Zebrafish
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of bre recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for bre. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
43,829 Da
NCBI Official Full Name
BRISC and BRCA1-A complex member 2
NCBI Official Synonym Full Names
BRISC and BRCA1 A complex member 2
NCBI Official Symbol
babam2  [Similar Products]
NCBI Official Synonym Symbols
bre; im:7141046; zgc:110368
  [Similar Products]
NCBI Protein Information
BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE
UniProt Protein Name
BRISC and BRCA1-A complex member 2
UniProt Synonym Protein Names
BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein
Protein Family
UniProt Gene Name
babam2  [Similar Products]
UniProt Synonym Gene Names
UniProt Comments for bre
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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