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BST2 positive control

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Catalog # MBS542577
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  5 Applications  /  $290 +1 FREE 8GB USB
BST2 positive control
Product Name

BST2, Positive Control

Full Product Name

BST2 Positive Control

Product Synonym Names
Bone marrow stromal antigen 2; Bone marrow stromal cell antigen 2; BST 2; CD 317; CD317 antigen; HM1.24 antigen; NPC A 7; Tetherin antibody
Matching Pairs
Antibody: BST2 (MBS540010)
Positive Control: BST2 (MBS542577)
Matching Pairs
Antibody: BST2 (MBS540223)
Positive Control: BST2 (MBS542577)
Matching Pairs
Antibody: BST2 (MBS540283)
Positive Control: BST2 (MBS542577)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600534
3D Structure
ModBase 3D Structure for Q10589
Form/Format
Western Blot Positive Control
Immunogen
Purified Protein
Expression
Liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal msucle and brain. Overexpressed in multiple myeloma cells. B-cells, T-cells, monocytes, NK cells and dendritic cells. Induced by type I interforns. Down regulated by viral antagonistic factors.
Molecular Function
Antiviral defense; B-cell activation; Immunity; Innate immunity
Structure
Parallel homodimer; disulfide linked. Cytoplasmic domain interacts with ARHGAP44 and MMP14.
Subcellular Location
Gogli apparatus, trans-golgi network; Cell membrane, Single-pass type II membrane protein. Lipid anchor, GPI anchor; Late endosome; Membrane raft; Cytoplasm; Apical cell membrane
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of BST2 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
BST2 positive control
Western Blot Positive Control Bonemarrow stromal antigen 2
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells.
Applications Tested/Suitable for BST2 positive control
Western Blot (WB)
Application Notes for BST2 positive control
Western Blot: 1:500-1:1,000
NCBI/Uniprot data below describe general gene information for BST2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,394 Da
NCBI Official Full Name
bone marrow stromal cell antigen 2 variant, partial
NCBI Official Synonym Full Names
bone marrow stromal cell antigen 2
NCBI Official Symbol
NCBI Official Synonym Symbols
CD317; TETHERIN
  [Similar Products]
NCBI Protein Information
bone marrow stromal antigen 2
UniProt Protein Name
Bone marrow stromal antigen 2
UniProt Synonym Protein Names
HM1.24 antigen; Tetherin; CD_antigen: CD317
UniProt Gene Name
UniProt Synonym Gene Names
BST-2  [Similar Products]
UniProt Entry Name
BST2_HUMAN
NCBI Summary for BST2
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]
UniProt Comments for BST2
BST2: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma- associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Belongs to the tetherin family.

Protein type: Cell development/differentiation; Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: apical plasma membrane; cell surface; cytoplasm; Golgi apparatus; integral to plasma membrane; late endosome; lipid raft; membrane; multivesicular body; plasma membrane

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protein homodimerization activity; signal transducer activity

Biological Process: B cell activation; cell proliferation; cell-cell signaling; defense response to virus; humoral immune response; innate immune response; multicellular organismal development; negative regulation of cell growth; negative regulation of cell migration; negative regulation of plasmacytoid dendritic cell cytokine production; negative regulation of viral genome replication; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of actin cytoskeleton organization and biogenesis; response to virus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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